Abstract：
UNASSIGNED: To analyze differences in the menstrual pattern, age at menarche, and body mass index (BMI) in adolescents with Hypothalamic-Pituitary-Ovarian (HPO) axis immaturity and Polycystic Ovary Syndrome (PCOS) through a systematic review and meta-analysis.
UNASSIGNED: The PubMed, EMBASE, Web of Science, Virtual Health Library, Scopus databases were searched using combinations of descriptors. Study quality was assessed using the Newcastle-Ottawa Scale. For data analysis, the results were grouped into PCOS group and NPCOS group (HPO axis immaturity). We performed a meta-analysis of raw data and the inverse variance method, employing the standardized mean difference, of the age at menarche and BMI of adolescents.
UNASSIGNED: Participants totaled 1,718 from nine selected studies. The meta-analysis showed that the PCOS group had a higher BMI than the NPCOS group (SMD 0.334; CI95% 0.073 - 0.595; p = .012). The degree of heterogeneity of the studies was approximately 40%. No significant difference in age at menarche (SMD - 0.027; CI95% -0.227 - 0.172; p = 0.790) and menstrual patterns was found, but amenorrhea was described only in adolescents with PCOS.
UNASSIGNED: The main characteristic in menstrual pattern that differentiated PCOS patients from girls with HPO axis immaturity was amenorrhea. Also, the BMI of PCOS patients was nearly one third higher than that of adolescents with HPO axis immaturity.
UNASSIGNED: The PubMed, EMBASE, Web of Science, Virtual Health Library, Scopus databases were searched using combinations of descriptors. Study quality was assessed using the Newcastle-Ottawa Scale. For data analysis, the results were grouped into PCOS group and NPCOS group (HPO axis immaturity). We performed a meta-analysis of raw data and the inverse variance method, employing the standardized mean difference, of the age at menarche and BMI of adolescents.
UNASSIGNED: Participants totaled 1,718 from nine selected studies. The meta-analysis showed that the PCOS group had a higher BMI than the NPCOS group (SMD 0.334; CI95% 0.073 - 0.595; p = .012). The degree of heterogeneity of the studies was approximately 40%. No significant difference in age at menarche (SMD - 0.027; CI95% -0.227 - 0.172; p = 0.790) and menstrual patterns was found, but amenorrhea was described only in adolescents with PCOS.
UNASSIGNED: The main characteristic in menstrual pattern that differentiated PCOS patients from girls with HPO axis immaturity was amenorrhea. Also, the BMI of PCOS patients was nearly one third higher than that of adolescents with HPO axis immaturity.
摘要：
■为了分析月经模式的差异，初潮年龄,通过系统评价和荟萃分析，对患有下丘脑-垂体-卵巢（HPO）轴不成熟和多囊卵巢综合征（PCOS）的青少年体重指数（BMI）进行了研究。
■PubMed，EMBASE,WebofScience,虚拟健康图书馆,使用描述符的组合搜索Scopus数据库。使用纽卡斯尔-渥太华量表评估研究质量。对于数据分析，结果分为PCOS组和NPCOS组（HPO轴不成熟）。我们对原始数据和逆方差方法进行了荟萃分析，采用标准化的平均差，青少年初潮年龄和BMI。
■来自9项选定研究的参与者总计1,718人。荟萃分析显示，PCOS组的BMI高于NPCOS组（SMD0.334；CI95％0.073-0.595；p=0.012）。研究的异质性程度约为40％。月经初潮年龄无显著差异(SMD-0.027;CI95%-0.227-0.172;p=0.790),但闭经仅见于PCOS青少年.
■将PCOS患者与患有HPO轴不成熟的女孩区分开的月经模式的主要特征是闭经。此外，PCOS患者的BMI比HPO轴不成熟的青少年高近1/3.
■PubMed，EMBASE,WebofScience,虚拟健康图书馆,使用描述符的组合搜索Scopus数据库。使用纽卡斯尔-渥太华量表评估研究质量。对于数据分析，结果分为PCOS组和NPCOS组（HPO轴不成熟）。我们对原始数据和逆方差方法进行了荟萃分析，采用标准化的平均差，青少年初潮年龄和BMI。
■来自9项选定研究的参与者总计1,718人。荟萃分析显示，PCOS组的BMI高于NPCOS组（SMD0.334；CI95％0.073-0.595；p=0.012）。研究的异质性程度约为40％。月经初潮年龄无显著差异(SMD-0.027;CI95%-0.227-0.172;p=0.790),但闭经仅见于PCOS青少年.
■将PCOS患者与患有HPO轴不成熟的女孩区分开的月经模式的主要特征是闭经。此外，PCOS患者的BMI比HPO轴不成熟的青少年高近1/3.
