PDF(Pubmed)
Abstract：
Knowledge about the mechanisms underlying the fluid flow in the brain and spinal cord is essential for discovering the mechanisms implicated in the pathophysiology of central nervous system diseases. During recent years, research has highlighted the complexity of the fluid flow movement in the brain through a glymphatic system and a lymphatic network. Less is known about these pathways in the spinal cord. An important aspect of fluid flow movement through the glymphatic pathway is the role of water channels, especially aquaporin 1 and 4. This review provides an overview of the role of these aquaporins in brain and spinal cord, and give a short introduction to the fluid flow in brain and spinal cord during in the healthy brain and spinal cord as well as during traumatic brain and spinal cord injury. Finally, this review gives an overview of the current knowledge about the role of aquaporins in traumatic brain and spinal cord injury, highlighting some of the complexities and knowledge gaps in the field.
摘要：
了解大脑和脊髓中流体流动的潜在机制对于发现与中枢神经系统疾病的病理生理学有关的机制至关重要。近年来,研究强调了通过淋巴系统和淋巴网络在大脑中流动的流体的复杂性。关于脊髓中的这些途径知之甚少。流体流动通过淋巴通路的一个重要方面是水通道的作用，特别是水通道蛋白1和4。这篇综述概述了这些水通道蛋白在大脑和脊髓中的作用。并简要介绍健康大脑和脊髓以及创伤性大脑和脊髓损伤期间大脑和脊髓中的液体流动。最后,这篇综述概述了水通道蛋白在创伤性脑和脊髓损伤中的作用，突出了该领域的一些复杂性和知识差距。
