PDF(Pubmed)
Abstract：
UNASSIGNED: Interleukin-18 (IL-18), also known as interferon-gamma inducing factor is a protein which in humans is encoded by the IL18 gene, it is a member of the IL 1 family and has a molecular weight of 18 kDa. Innate and adaptive immunity can be regulated by IL-18, and disorders involving its dysregulation might result in inflammatory or autoimmune conditions.
UNASSIGNED: To distinguish between acute kidney injury (AKI) and chronic renal failure (CRF), this research investigates the utility of IL-18 as a novel biomarker and examines how age affects its level.
UNASSIGNED: Three hundred participants were included and divided into three groups using the following methodology. Group I consisted of 100 control subjects who were split up by age and gender. Group II consisted of 100 AKI patients who were divided into two groups and subgroups based on age and gender. Group III, which consisted of 100 CRF (hemodialyzed patients), was divided into two groups and subgroups, as patients with acute renal injury and previously healthy people. Patients\' blood was drawn to conduct a laboratory investigation blood urea, serum creatinine, sodium, potassium, pH, GFR and PCO2.
UNASSIGNED: Patients with CRF had higher serum levels of IL-18 than patients with AKI, regardless of gender, and both groups of patients had levels of IL-18 that rise with age.
UNASSIGNED: IL-18 is a reliable indicator for the differentiation between AKI and CRF patients receiving hemodialysis and its level correlates with age independent with gender.
UNASSIGNED: To distinguish between acute kidney injury (AKI) and chronic renal failure (CRF), this research investigates the utility of IL-18 as a novel biomarker and examines how age affects its level.
UNASSIGNED: Three hundred participants were included and divided into three groups using the following methodology. Group I consisted of 100 control subjects who were split up by age and gender. Group II consisted of 100 AKI patients who were divided into two groups and subgroups based on age and gender. Group III, which consisted of 100 CRF (hemodialyzed patients), was divided into two groups and subgroups, as patients with acute renal injury and previously healthy people. Patients\' blood was drawn to conduct a laboratory investigation blood urea, serum creatinine, sodium, potassium, pH, GFR and PCO2.
UNASSIGNED: Patients with CRF had higher serum levels of IL-18 than patients with AKI, regardless of gender, and both groups of patients had levels of IL-18 that rise with age.
UNASSIGNED: IL-18 is a reliable indicator for the differentiation between AKI and CRF patients receiving hemodialysis and its level correlates with age independent with gender.
摘要：
■白细胞介素-18（IL-18），也称为干扰素-γ诱导因子是一种在人类中由IL18基因编码的蛋白质，它是IL1家族的成员，分子量为18kDa。固有和适应性免疫可以由IL-18调节,并且涉及其失调的病症可能导致炎症或自身免疫病症。
■为了区分急性肾损伤（AKI）和慢性肾衰竭（CRF），这项研究调查了IL-18作为一种新型生物标志物的效用,并研究了年龄如何影响其水平.
■纳入了300名参与者，并使用以下方法将其分为三组。第一组由100名对照受试者组成，他们按年龄和性别分开。第二组由100名AKI患者组成，根据年龄和性别分为两组和亚组。第三组,其中包括100名CRF（血液透析患者），分为两组和亚组，作为急性肾损伤患者和以前健康的人。患者抽血进行实验室调查血尿素，血清肌酐,钠,钾，pH值,GFR和PCO2。
■CRF患者的血清IL-18水平高于AKI患者，不分性别,两组患者的IL-18水平均随年龄增长而升高。
■IL-18是区分接受血液透析的AKI和CRF患者的可靠指标，其水平与年龄和性别无关。
■为了区分急性肾损伤（AKI）和慢性肾衰竭（CRF），这项研究调查了IL-18作为一种新型生物标志物的效用,并研究了年龄如何影响其水平.
■纳入了300名参与者，并使用以下方法将其分为三组。第一组由100名对照受试者组成，他们按年龄和性别分开。第二组由100名AKI患者组成，根据年龄和性别分为两组和亚组。第三组,其中包括100名CRF（血液透析患者），分为两组和亚组，作为急性肾损伤患者和以前健康的人。患者抽血进行实验室调查血尿素，血清肌酐,钠,钾，pH值,GFR和PCO2。
■CRF患者的血清IL-18水平高于AKI患者，不分性别,两组患者的IL-18水平均随年龄增长而升高。
■IL-18是区分接受血液透析的AKI和CRF患者的可靠指标，其水平与年龄和性别无关。
