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Abstract：
Over the past 10 years, the biological role of lipid droplets (LDs) has gained significant attention in the context of both physiological and pathological conditions. Considerable progress has been made in elucidating key aspects of these organelles, yet much remains to be accomplished to fully comprehend the myriad functions they serve in the progression of hepatic tumors. Our current perception is that LDs are complex and active structures managed by a distinct set of cellular processes. This understanding represents a significant paradigm shift from earlier perspectives. In this review, we aim to recapitulate the function of LDs within the liver, highlighting their pivotal role in the pathogenesis of metabolic dysfunction-associated steatotic liver disease (MASLD) (Hsu and Loomba, 2024) and their contribution to the progression towards more advanced pathological stages up to hepatocellular carcinoma (HC) (Farese and Walther, 2009). We are aware of the molecular complexity and changes occurring in the neoplastic evolution of the liver. Our attempt, however, is to summarize the most important and recent roles of LDs across both healthy and all pathological liver states, up to hepatocarcinoma. For more detailed insights, we direct readers to some of the many excellent reviews already available in the literature (Gluchowski et al., 2017; Hu et al., 2020; Seebacher et al., 2020; Paul et al., 2022).
摘要：
在过去的10年里,在生理和病理条件下,脂滴(LDs)的生物学作用已获得显著关注。在阐明这些细胞器的关键方面已经取得了相当大的进展，然而，要完全理解它们在肝肿瘤进展中的无数功能，还有很多工作要做。我们目前的看法是，LD是由一组不同的细胞过程管理的复杂而活跃的结构。这种理解代表了早期观点的重大范式转变。在这次审查中,我们的目的是概述肝脏中LD的功能，强调它们在代谢功能障碍相关的脂肪变性肝病（MASLD）的发病机理中的关键作用（Hsu和Loomba，2024)及其对肝细胞癌(HC)的更晚期病理阶段进展的贡献(Farese和Walther，2009).我们知道肝脏肿瘤演变过程中发生的分子复杂性和变化。我们的尝试，然而,是总结LD在健康和所有病理肝脏状态中最重要和最近的作用，直到肝癌。有关更详细的见解，我们引导读者阅读文献中已有的许多优秀评论(Gluchowski等人。,2017；胡等人。,2020年；Seebacher等人。,2020年；保罗等人。,2022年）。
