PDF(Pubmed)
Abstract：
RNA turnover plays critical roles in the regulation of gene expression and allows cells to respond rapidly to environmental changes. In bacteria, the mechanisms of RNA turnover have been extensively studied in the models Escherichia coli and Bacillus subtilis, but not much is known in other bacteria. Cyanobacteria are a diverse group of photosynthetic organisms that have great potential for the sustainable production of valuable products using CO2 and solar energy. A better understanding of the regulation of RNA decay is important for both basic and applied studies of cyanobacteria. Genomic analysis shows that cyanobacteria have more than 10 ribonucleases and related proteins in common with E. coli and B. subtilis, and only a limited number of them have been experimentally investigated. In this review, we summarize the current knowledge about these RNA-turnover-related proteins in cyanobacteria. Although many of them are biochemically similar to their counterparts in E. coli and B. subtilis, they appear to have distinct cellular functions, suggesting a different mechanism of RNA turnover regulation in cyanobacteria. The identification of new players involved in the regulation of RNA turnover and the elucidation of their biological functions are among the future challenges in this field.
摘要：
RNA转换在基因表达的调节中起着关键作用，并允许细胞对环境变化做出快速反应。在细菌中，RNA周转的机制已经在大肠杆菌和枯草芽孢杆菌模型中进行了广泛的研究，但对其他细菌了解不多。蓝细菌是一组不同的光合生物，具有使用CO2和太阳能可持续生产有价值产品的巨大潜力。更好地了解RNA衰变的调节对于蓝细菌的基础和应用研究都很重要。基因组分析表明，蓝藻与大肠杆菌和枯草芽孢杆菌有10种以上的核糖核酸酶和相关蛋白，只有有限数量的他们已经被实验研究。在这次审查中,我们总结了有关蓝细菌中这些RNA周转相关蛋白的最新知识。尽管它们中的许多与大肠杆菌和枯草芽孢杆菌的生化相似，它们似乎有不同的细胞功能，表明蓝细菌中RNA周转调节的不同机制。鉴定参与RNA周转调节的新参与者及其生物学功能的阐明是该领域未来的挑战之一。
