PDF(Pubmed)
Abstract：
In this editorial we comment on the review by Zhou et al reviewing the landscape of nanomedicine in the treatment of hepatocellular carcinoma (HCC). We focus on the immense potential of nanotechnology, particularly ligand-receptor mediated nanotherapy, in revolutionizing the treatment landscape of HCC. Despite advancements in multidisciplinary treatment, HCC remains a significant global health challenge. Ligand-mediated nanotherapy offers the opportunity for precise drug delivery to tumor sites, targeting specific receptors overexpressed in HCC cells, thereby enhancing efficacy and minimizing side effects. Overcoming drug resistance and aggressive tumor biology is facilitated by nanomedicine, bypassing traditional hurdles encountered in chemotherapy. Examples include targeting glypican-3, asialoglycoprotein, transferrin receptor or folic acid receptors, capitalizing on their over-expression in tumor cells. The ability for multi-receptor targeting through dual-ligand nanoparticle modification holds the prospect of further enhancement in specificity and efficacy of directed therapy. However, challenges including immune responses, reproducibility in nanoparticle synthesis, and production scalability remain. Future directions involve refining targeting strategies, improving drug release mechanisms, and streamlining production processes to enable personalized and multifunctional nanotherapies. Overall, the integration of nanotherapy in HCC treatment holds immense promise, but continued partnership and effort are needed in offering hope for more effective, precise, and accessible clinical care in the management of HCC.
摘要：
在这篇社论中，我们评论了Zhou等人的评论，回顾了纳米医学在肝细胞癌（HCC）治疗中的前景。我们专注于纳米技术的巨大潜力，特别是配体受体介导的纳米疗法，彻底改变HCC的治疗前景。尽管多学科治疗取得了进展，HCC仍然是一个重大的全球健康挑战。配体介导的纳米治疗提供了精确的药物递送到肿瘤部位的机会，靶向肝癌细胞中过表达的特异性受体，从而提高疗效和减少副作用。克服耐药性和侵袭性肿瘤生物学是由纳米医学，绕过化疗中遇到的传统障碍。例子包括靶向磷脂酰肌醇蛋白聚糖-3，去唾液酸糖蛋白，转铁蛋白受体或叶酸受体，利用它们在肿瘤细胞中的过度表达。通过双配体纳米颗粒修饰的多受体靶向的能力具有进一步增强定向治疗的特异性和功效的前景。然而,挑战包括免疫反应，纳米粒子合成的再现性，和生产可扩展性保持不变。未来的方向包括完善目标战略，改善药物释放机制，并简化生产流程，以实现个性化和多功能纳米疗法。总的来说,纳米疗法在肝癌治疗中的整合有着巨大的前景，但是需要持续的伙伴关系和努力来提供更有效的希望，精确，和肝癌管理中可获得的临床护理。
