PDF(Pubmed)
Abstract：
Non-alcoholic fatty liver disease (NAFLD) encompasses a spectrum of liver disorders of varying severity, ultimately leading to fibrosis. This spectrum primarily consists of NAFL and non-alcoholic steatohepatitis. The pathogenesis of NAFLD is closely associated with disturbances in the gut microbiota and impairment of the intestinal barrier. Non-gut commensal flora, particularly bacteria, play a pivotal role in the progression of NAFLD. Notably, Porphyromonas gingivalis, a principal bacterium involved in periodontitis, is known to facilitate lipid accumulation, augment immune responses, and induce insulin resistance, thereby exacerbating fibrosis in cases of periodontitis-associated NAFLD. The influence of oral microbiota on NAFLD via the \"oral-gut-liver\" axis is gaining recognition, offering a novel perspective for NAFLD management through microbial imbalance correction. This review endeavors to encapsulate the intricate roles of oral bacteria in NAFLD and explore underlying mechanisms, emphasizing microbial control strategies as a viable therapeutic avenue for NAFLD.
摘要：
非酒精性脂肪性肝病（NAFLD）包括一系列严重程度不同的肝脏疾病，最终导致纤维化。该频谱主要由NAFL和非酒精性脂肪性肝炎组成。NAFLD的发病机制与肠道菌群紊乱和肠道屏障受损密切相关。非肠共生菌群，特别是细菌，在NAFLD的进展中起关键作用。值得注意的是,牙龈卟啉单胞菌,与牙周炎有关的主要细菌，已知促进脂质积累，增强免疫反应，并诱导胰岛素抵抗，从而加剧牙周炎相关NAFLD病例的纤维化。口腔微生物群通过“口腔-肠道-肝脏”轴对NAFLD的影响正在获得认可，通过微生物失衡校正为NAFLD管理提供了新的视角。这篇综述试图囊括口腔细菌在NAFLD中的复杂作用，并探索潜在的机制。强调微生物控制策略是NAFLD的可行治疗途径。
