PDF(Pubmed)
Abstract：
UNASSIGNED: Concerns regarding restenosis after treatment with drug-coated balloons (DCB) remain. We aimed to identify the incidence of target lesion revascularization (TLR) and explore clinical, procedural, and other factors influencing it.
UNASSIGNED: Single-center retrospective analysis of a prospective cohort PCI registry study included 80 patients (100 lesions) who underwent successful DCB angioplasty between January 2020 and October 2023 and follow-up angiography within 2 years of either planned or unplanned reason. Incidence and factors associated with TLR were analyzed.
UNASSIGNED: Angiographic evaluation was conducted within a median of 151 days (interquartile range: 109 days). During index procedure, 54% were complex lesions. Intravascular imaging (IVI) was performed in 80% of lesions. TLR occurred in 11% of the lesions and was less frequent in the IVI group compared to the angiography-alone group [6.3 vs. 54.5%; odds ratio: 0.156, 95% confidence interval (CI): 0.042-0.580; p = 0.002]. No association was found between baseline and lesion characteristics, lesion complexity, plaque morphology, pre-dilatation procedure balloon type, maximal inflation pressure, or length of DCB between the groups (p > 0.05). Multivariate analysis revealed that IVI utilization was independently associated with a lower TLR rate (adjusted odds ratio: 0.116, 95% CI: 0.020-0.669; p = 0.016).
UNASSIGNED: In DCB angioplasty, only IVI use exhibited a significant difference in the TLR rate among baseline lesion characteristics and lesion preparation and was independently associated with a lower TLR rate.
UNASSIGNED: Single-center retrospective analysis of a prospective cohort PCI registry study included 80 patients (100 lesions) who underwent successful DCB angioplasty between January 2020 and October 2023 and follow-up angiography within 2 years of either planned or unplanned reason. Incidence and factors associated with TLR were analyzed.
UNASSIGNED: Angiographic evaluation was conducted within a median of 151 days (interquartile range: 109 days). During index procedure, 54% were complex lesions. Intravascular imaging (IVI) was performed in 80% of lesions. TLR occurred in 11% of the lesions and was less frequent in the IVI group compared to the angiography-alone group [6.3 vs. 54.5%; odds ratio: 0.156, 95% confidence interval (CI): 0.042-0.580; p = 0.002]. No association was found between baseline and lesion characteristics, lesion complexity, plaque morphology, pre-dilatation procedure balloon type, maximal inflation pressure, or length of DCB between the groups (p > 0.05). Multivariate analysis revealed that IVI utilization was independently associated with a lower TLR rate (adjusted odds ratio: 0.116, 95% CI: 0.020-0.669; p = 0.016).
UNASSIGNED: In DCB angioplasty, only IVI use exhibited a significant difference in the TLR rate among baseline lesion characteristics and lesion preparation and was independently associated with a lower TLR rate.
摘要：
■关于用药物涂层球囊(DCB)治疗后再狭窄的担忧仍然存在。我们旨在确定靶病变血运重建(TLR)的发生率,程序,以及其他影响因素。
■一项前瞻性队列PCI注册研究的单中心回顾性分析包括在2020年1月至2023年10月期间成功接受DCB血管成形术的80例患者（100个病灶），并在计划内或计划外原因的2年内进行了血管造影随访。分析TLR的发生率及相关因素。
■在151天的中位数内进行血管造影评估（四分位距：109天）。在索引过程中，54%为复杂病变。在80％的病变中进行了血管内成像（IVI）。TLR发生在11％的病变中，与单纯血管造影组相比，IVI组的发生率较低[6.3vs.54.5%；比值比：0.156，95%置信区间（CI）：0.042-0.580；p=0.002]。基线和病变特征之间没有发现关联，病变复杂性,斑块形态,预扩张程序球囊类型，最大充气压力,或组间DCB的长度(p>0.05)。多变量分析显示，IVI利用率与较低的TLR率独立相关（校正比值比：0.116，95％CI：0.020-0.669；p=0.016）。
■在DCB血管成形术中，仅IVI使用在基线病变特征和病变准备中显示TLR率存在显著差异,并且与较低TLR率独立相关.
■一项前瞻性队列PCI注册研究的单中心回顾性分析包括在2020年1月至2023年10月期间成功接受DCB血管成形术的80例患者（100个病灶），并在计划内或计划外原因的2年内进行了血管造影随访。分析TLR的发生率及相关因素。
■在151天的中位数内进行血管造影评估（四分位距：109天）。在索引过程中，54%为复杂病变。在80％的病变中进行了血管内成像（IVI）。TLR发生在11％的病变中，与单纯血管造影组相比，IVI组的发生率较低[6.3vs.54.5%；比值比：0.156，95%置信区间（CI）：0.042-0.580；p=0.002]。基线和病变特征之间没有发现关联，病变复杂性,斑块形态,预扩张程序球囊类型，最大充气压力,或组间DCB的长度(p>0.05)。多变量分析显示，IVI利用率与较低的TLR率独立相关（校正比值比：0.116，95％CI：0.020-0.669；p=0.016）。
■在DCB血管成形术中，仅IVI使用在基线病变特征和病变准备中显示TLR率存在显著差异,并且与较低TLR率独立相关.
