PDF(Pubmed)
Abstract：
The gastrointestinal tract is an important part of the human immune system. The gut microbiome, which constitutes a major component of the gastrointestinal tract, plays a crucial role in maintaining normal physiological functions and influences the development, diagnosis, and immunotherapy of colorectal cancer (CRC). Natural polysaccharides can be extracted from animals, plants, and traditional Chinese medicines. They serve as an essential energy source for the gut microbiome, promoting probiotic proliferation and regulating the intestinal microecological balance. Moreover, polysaccharides exhibit anti-tumor effects due to their immune regulatory functions and low toxicity. This review focuses on discussing these anti-tumor effects in CRC, along with improving gut microbiome dysbiosis and regulating the tumor immune microenvironment, providing evidence for effective therapeutic strategies against CRC.
摘要：
胃肠道是人体免疫系统的重要组成部分。肠道微生物组，构成胃肠道的主要组成部分，在维持正常生理功能和影响发育中起着至关重要的作用，诊断,和大肠癌（CRC）的免疫治疗。天然多糖可以从动物中提取，植物,和中药。它们是肠道微生物组的重要能量来源，促进益生菌增殖，调节肠道微生态平衡。此外，多糖由于其免疫调节功能和低毒性而具有抗肿瘤作用。本文就这些在CRC中的抗肿瘤作用进行综述,随着改善肠道微生物群失调和调节肿瘤免疫微环境，为针对CRC的有效治疗策略提供证据。
