PDF(Pubmed)
Abstract：
Neuroendocrine tumours (NETs) originating from extrahepatic bile duct are an extremely rare entity. They are typically slow growing tumours with malignant potential. Commonly presenting as obstructive jaundice, preoperative clinico-radiologic differentiation between extrahepatic biliary tract neuroendocrine tumours and cholangiocarcinoma is difficult and the final diagnosis is usually established after surgical histopathology and immunohistochemistry examination. R0 resection offers the only curative option with good long-term outcomes for well-differentiated NETs (grade1, grade2, and grade3) while the aggressive poorly differentiated neuroendocrine carcinoma (NEC) needs multimodality approach. We present our experience of management of four cases including three cases of grade II NET and one case of NEC undergoing surgical resection at a single centre with a short review of available literature.
摘要：
起源于肝外胆管的神经内分泌肿瘤（NETs）是一种极为罕见的实体。它们通常是具有恶性潜力的缓慢生长的肿瘤。通常表现为阻塞性黄疸，肝外胆道神经内分泌肿瘤和胆管癌之间的术前临床放射学鉴别是困难的，最终诊断通常在手术组织病理学和免疫组织化学检查后确定。R0切除为分化良好的NETs（1级，2级和3级）提供了唯一具有良好长期疗效的治疗选择，而侵袭性低分化神经内分泌癌（NEC）则需要多模式治疗。我们介绍了我们在单个中心接受手术切除的4例病例的管理经验，其中包括3例II级NET和1例NEC，并对现有文献进行了简短回顾。
