PDF(Pubmed)
Abstract：
No reports on granulocyte colony-stimulating factor-producing lung cancer associated with antiphospholipid antibody syndrome. A 73-year-old man was referred to our department to undergo surgery for lung cancer in the right upper lobe. His examination results suggested that his condition was caused by an elevated white blood cell count and an increased inflammatory response due to granulocyte colony-stimulating factor production. The presence of antiphospholipid antibody syndrome was suspected, and the decrease in coagulation factors was considered to be inhibited by the lupus anticoagulant. Perioperatively, the patient was treated with heparin and steroids, and a thoracoscopically assisted right upper lobectomy was performed. Postoperatively, histopathological examination revealed pleomorphic carcinoma, and the patient tested negative for anticardiolipin IgG antibodies. In lung cancer patients with elevated white blood cell counts, fever, and an inflammatory response, granulocyte colony-stimulating factor-producing lung cancer is an important differential diagnosis. Additionally, when coagulation abnormalities are observed preoperatively, a thorough examination is necessary to prepare for perioperative management.
摘要：
无与抗磷脂抗体综合征相关的粒细胞集落刺激因子产生肺癌的报道。一名73岁的男子被转介到我们部门接受右上叶肺癌手术。他的检查结果表明，他的病情是由白细胞计数升高和粒细胞集落刺激因子产生引起的炎症反应增加引起的。怀疑存在抗磷脂抗体综合征，凝血因子的减少被认为是由狼疮抗凝药抑制的。围手术期,患者接受了肝素和类固醇治疗，并进行了胸腔镜辅助的右上叶切除术。术后,组织病理学检查显示多形性癌，患者抗心磷脂IgG抗体检测呈阴性。在白细胞计数升高的肺癌患者中，发烧,和炎症反应，产生粒细胞集落刺激因子的肺癌是一种重要的鉴别诊断.此外,当术前观察到凝血异常时，彻底的检查是必要的准备围手术期管理。
