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Abstract：
Primary amyloidosis of the conjunctiva and eyelid is a rare and often misdiagnosed condition. It is characterized by the deposition of insoluble amyloid fibrils, which are misfolded proteins, in the body. Amyloidosis can be systemic or localized with different types of amyloid fibril proteins identified using mass spectrometry. Ocular involvement in amyloidosis can lead to corneal dystrophies, glaucoma, vitreous opacities, and other symptoms. Diagnosis involves clinical examination and histopathological assessment. Treatment options depend on the extent of involvement and may include surgical excision, glaucoma management, vitrectomy, or liver transplantation in rare cases. We present a rare case of localized conjunctival amyloidosis initially misdiagnosed as pyogenic granuloma, with clinical symptoms of ptosis, periorbital swelling, and conjunctival lesions. The patient underwent excision of the lesions, and subsequent evaluation did not reveal systemic amyloidosis. Ocular amyloidosis requires careful diagnosis and consideration of systemic involvement for appropriate management.
摘要：
结膜和眼睑的原发性淀粉样变性是一种罕见且经常误诊的疾病。它的特征是不溶性淀粉样纤维的沉积，是错误折叠的蛋白质，在身体里。淀粉样变性可以是全身性的或使用质谱鉴定的不同类型的淀粉样原纤维蛋白的局部化的。淀粉样变性的眼部受累可导致角膜营养不良，青光眼,玻璃体混浊,和其他症状。诊断包括临床检查和组织病理学评估。治疗方案取决于受累程度，可能包括手术切除，青光眼管理，玻璃体切除术,或在极少数情况下进行肝移植。我们介绍了一个罕见的局部结膜淀粉样变性病例，最初被误诊为化脓性肉芽肿，伴有上睑下垂的临床症状，眶周肿胀,和结膜病变。病人接受了病灶切除,随后的评估没有发现系统性淀粉样变性。眼部淀粉样变性需要仔细诊断，并考虑全身参与以进行适当的治疗。
