PDF(Pubmed)
Abstract：
Cytomegalovirus (CMV) is a DNA virus that can cause widespread, severe infection in immunocompromised patients. While CMV usually leads to a subclinical infection in immunocompetent individuals, it can rarely cause severe disease in this population. The SARS-CoV-2 virus is an RNA virus and part of the Coronaviridae family. SARS-CoV-2 led to the COVID-19 (coronavirus disease 2019) pandemic. Even though COVID-19 usually presents with signs and symptoms of upper respiratory tract infection in younger adults, viral pneumonia, cytopenia, and neurological symptoms become more apparent with increasing age. Herein, we describe an immunocompetent 73-year-old female patient in whom oxygen demand and pancytopenia developed during hospitalization for post-ablation inguinal access site infection. The thorax CT revealed viral pneumonia, but two subsequent SARS-CoV-2 polymerase chain reaction (PCR) tests and a viral respiratory multiplex PCR panel were negative. The CMV viral load was high in the blood sample, and the patient responded to valganciclovir treatment. Although SARS-CoV-2 should be evaluated in patients with viral pneumonia and cytopenia, other viral etiologies mimicking SARS-CoV-2 infection, such as CMV, should not be overlooked in the era of the COVID-19 pandemic.
摘要：
巨细胞病毒(CMV)是一种DNA病毒,免疫功能低下患者的严重感染。虽然CMV通常导致免疫活性个体的亚临床感染，它很少会在这个人群中引起严重的疾病。SARS-CoV-2病毒是一种RNA病毒，是冠状病毒科的一部分。SARS-CoV-2导致了COVID-19（2019年冠状病毒病）大流行。尽管COVID-19通常在年轻人中出现上呼吸道感染的体征和症状，病毒性肺炎,血细胞减少,随着年龄的增长，神经系统症状变得更加明显。在这里，我们描述了一名有免疫能力的73岁女性患者,该患者因消融术后腹股沟入路部位感染在住院期间出现需氧量和全血细胞减少.胸部CT显示病毒性肺炎,但是随后的两次SARS-CoV-2聚合酶链反应（PCR）测试和病毒呼吸道多重PCR面板均为阴性。血液样本中的CMV病毒载量很高，患者对伐更昔洛韦治疗有反应。尽管SARS-CoV-2应该在病毒性肺炎和血细胞减少症患者中进行评估，其他病毒病因学模拟SARS-CoV-2感染，如CMV，在COVID-19大流行的时代，不应该被忽视。
