PDF(Pubmed)
Abstract：
Inflammatory pseudotumor encompasses a spectrum of both neoplastic and non-neoplastic conditions characterized by a histological pattern featuring a proliferation of cytologically bland spindle cells, accompanied by a prominent chronic inflammatory infiltrate. Within this spectrum, inflammatory myofibroblastic tumor (IMT) has emerged as a distinct entity over the past two decades, marked by unique clinical, pathological, and molecular characteristics. Typically affecting the visceral soft tissues of children and adolescents, IMT exhibits a propensity for local recurrence while posing a minimal risk of distant metastasis. They are extremely rare in adults, constituting less than 1% of adult lung tumors. Our patient, a 63-year-old female, has an intricate medical background, encompassing chronic obstructive pulmonary disease (COPD), a previous history of smoking (35 pack-years, quit a year before admission), coronary artery disease, non-obstructive hypertrophic cardiomyopathy, and obstructive sleep apnea. Presenting with a diagnostic dilemma, she recently received treatment for non-small cell carcinoma with radiation therapy, which has evolved into a swiftly advancing case of IMT.
摘要：
炎性假瘤包括一系列肿瘤和非肿瘤疾病，其特征在于组织学模式，其特征是细胞学上温和的梭形细胞增殖。伴有明显的慢性炎症浸润。在这个光谱中，在过去的二十年中，炎性肌纤维母细胞瘤（IMT）已成为一种独特的实体，以独特的临床为标志，病态,和分子特征。通常会影响儿童和青少年的内脏软组织，IMT表现出局部复发的倾向，同时造成远处转移的风险最小。它们在成年人中极为罕见，占成人肺部肿瘤的不到1％。我们的病人,一位63岁的女性,有着复杂的医学背景,包括慢性阻塞性肺疾病（COPD），既往吸烟史（35包年，在入学前一年辞职)，冠状动脉疾病,非梗阻性肥厚型心肌病,和阻塞性睡眠呼吸暂停。呈现诊断困境，她最近接受了非小细胞癌的放射治疗，这已经演变成一个迅速推进的IMT案例。
