PDF(Pubmed)
Abstract：
Parvoviruses are ubiquitous pathogens that cause fatal disease in cats. Feline panleukopenia virus (FPV) is a primitive virus reported first and canine parvovirus (CPV) evolved from FPV and was reported later. Both induce disease in cats and dogs with correlative signs. FPV in domestic cats is genetically diverse and some strains may differ from those used for vaccination. In this study, a virus of FPV strain, ABT/MVC/2022/FPV/001, was identified from a fecal sample of the suspected cat with severe haemorrhagic gastroenteritis. The phylogenetic analysis and complete genome sequence of the strain share 99.75% nucleotide identity with FPV variant MH559110 belonging to Tamil Nadu, India. The results also reveal similarities to strains isolated from Italy, Belgium, and China. The deduced amino acid sequence of isolated strain revealed specific amino acid substitution (Pro5Ala, Phe6Val, His7Gln, Asn9Asp, Lys16Arg, Lys19Arg, Asn52Lys, Gly58Trp, Thr66Ser, Lys67Arg, Leu70His, Asn373Asp and Ala390Thr) which differed from MH559110 and other strains. The complete genomic analysis revealed that the FPV strain circulating in India is evolving rapidly with unique antigenic variations between field FPV, CPV and vaccine strains which may be the major cause for vaccine failure in vaccinated cats.
UNASSIGNED: The online version contains supplementary material available at 10.1007/s13337-023-00854-7.
UNASSIGNED: The online version contains supplementary material available at 10.1007/s13337-023-00854-7.
摘要：
细小病毒是引起猫致命疾病的普遍存在的病原体。猫泛白细胞减少症病毒（FPV）是最早报道的原始病毒，犬细小病毒（CPV）是从FPV进化而来的，后来才报道。两者都在猫和狗中诱发疾病，并伴有相关体征。家猫的FPV在遗传上是多样化的，一些菌株可能与用于疫苗接种的菌株不同。在这项研究中,FPV病毒株,从疑似患有严重出血性胃肠炎的猫的粪便样本中鉴定出ABT/MVC/2022/FPV/001。该菌株的系统发育分析和完整基因组序列与属于泰米尔纳德邦的FPV变体MH559110具有99.75％的核苷酸同一性，印度。结果还揭示了从意大利分离的菌株的相似性，比利时,和中国。分离菌株的推导氨基酸序列揭示了特定的氨基酸取代（Pro5Ala，Phe6Val,His7Gln,Asn9Asp,Lys16Arg,Lys19Arg,Asn52Lys,Gly58Trp,Thr66Ser,Lys67Arg,Leu70His,Asn373Asp和Ala390Thr）与MH559110和其他菌株不同。完整的基因组分析显示，在印度传播的FPV菌株正在迅速发展，在野外FPV之间具有独特的抗原变异，CPV和疫苗株可能是接种猫疫苗失败的主要原因。
■在线版本包含补充材料，可在10.1007/s13337-023-00854-7获得。
■在线版本包含补充材料，可在10.1007/s13337-023-00854-7获得。
