PDF(Pubmed)
Abstract：
BACKGROUND: Few studies have investigated the expression of GLI1 and PTTG1 in patients undergoing radical surgery for colorectal carcinoma (CRC) and their association with lymph node metastasis (LNM). Therefore, more relevant studies and analyses need to be conducted.
OBJECTIVE: To explore GLI1 and PTTG1 expression in patients undergoing radical surgery for CRC and their correlation with LNM.
METHODS: This study selected 103 patients with CRC admitted to our hospital between April 2020 and April 2023. Sample specimens of CRC and adjacent tissues were collected to determine the positive rates and expression levels of GLI1 and PTTG1. The correlation of the two genes with patients\' clinicopathological data (e.g., LNM) was explored, and differences in GLI1 and PTTG1 expression between patients with LNM and those without were analyzed. Receiver operating characteristic (ROC) curves were plotted to evaluate the predictive potential of the two genes for LNM in patients with CRC.
RESULTS: Significantly higher positive rates and expression levels of GLI1 and PTTG1 were observed in CRC tissue samples compared with adjacent tissues. GLI1 and PTTG1 were strongly linked to LNM in patients undergoing radical surgery for CRC, with higher GLI1 and PTTG1 levels found in patients with LNM than in those without. The areas under the ROC curve of GLI1 and PTTG1 in assessing LNM in patients with CRC were 0.824 and 0.811, respectively.
CONCLUSIONS: GLI1 and PTTG1 expression was upregulated in patients undergoing radical surgery for CRC and are significantly related to LNM in these patients. Moreover, high GLI1 and PTTG1 expression can indicate LNM in patients with CRC undergoing radical surgery. The expression of both genes has certain diagnostic and therapeutic significance.
OBJECTIVE: To explore GLI1 and PTTG1 expression in patients undergoing radical surgery for CRC and their correlation with LNM.
METHODS: This study selected 103 patients with CRC admitted to our hospital between April 2020 and April 2023. Sample specimens of CRC and adjacent tissues were collected to determine the positive rates and expression levels of GLI1 and PTTG1. The correlation of the two genes with patients\' clinicopathological data (e.g., LNM) was explored, and differences in GLI1 and PTTG1 expression between patients with LNM and those without were analyzed. Receiver operating characteristic (ROC) curves were plotted to evaluate the predictive potential of the two genes for LNM in patients with CRC.
RESULTS: Significantly higher positive rates and expression levels of GLI1 and PTTG1 were observed in CRC tissue samples compared with adjacent tissues. GLI1 and PTTG1 were strongly linked to LNM in patients undergoing radical surgery for CRC, with higher GLI1 and PTTG1 levels found in patients with LNM than in those without. The areas under the ROC curve of GLI1 and PTTG1 in assessing LNM in patients with CRC were 0.824 and 0.811, respectively.
CONCLUSIONS: GLI1 and PTTG1 expression was upregulated in patients undergoing radical surgery for CRC and are significantly related to LNM in these patients. Moreover, high GLI1 and PTTG1 expression can indicate LNM in patients with CRC undergoing radical surgery. The expression of both genes has certain diagnostic and therapeutic significance.
摘要：
背景：很少有研究研究GLI1和PTTG1在接受结直肠癌（CRC）根治性手术的患者中的表达及其与淋巴结转移（LNM）的关系。因此,需要进行更多相关的研究和分析。
目的：探讨接受CRC根治术的患者GLI1和PTTG1的表达及其与LNM的相关性。
方法：本研究选择了2020年4月至2023年4月我院收治的103例CRC患者。收集CRC和邻近组织的样品标本以确定GLI1和PTTG1的阳性率和表达水平。这两个基因与患者临床病理数据的相关性(例如，LNM)进行了探索，并分析了LNM患者和无LNM患者之间GLI1和PTTG1表达的差异。绘制受试者工作特征（ROC）曲线以评估两种基因在CRC患者中对LNM的预测潜力。
结果：与邻近组织相比，在CRC组织样本中观察到GLI1和PTTG1的阳性率和表达水平明显更高。在接受CRC根治性手术的患者中，GLI1和PTTG1与LNM密切相关，LNM患者的GLI1和PTTG1水平高于无LNM患者。评估CRC患者LNM时GLI1和PTTG1的ROC曲线下面积分别为0.824和0.811。
结论：GLI1和PTTG1的表达在接受CRC根治术的患者中上调，并且在这些患者中与LNM显著相关。此外，高GLI1和PTTG1表达可提示接受根治性手术的CRC患者存在LNM.这两种基因的表达均具有一定的诊断和治疗意义。
目的：探讨接受CRC根治术的患者GLI1和PTTG1的表达及其与LNM的相关性。
方法：本研究选择了2020年4月至2023年4月我院收治的103例CRC患者。收集CRC和邻近组织的样品标本以确定GLI1和PTTG1的阳性率和表达水平。这两个基因与患者临床病理数据的相关性(例如，LNM)进行了探索，并分析了LNM患者和无LNM患者之间GLI1和PTTG1表达的差异。绘制受试者工作特征（ROC）曲线以评估两种基因在CRC患者中对LNM的预测潜力。
结果：与邻近组织相比，在CRC组织样本中观察到GLI1和PTTG1的阳性率和表达水平明显更高。在接受CRC根治性手术的患者中，GLI1和PTTG1与LNM密切相关，LNM患者的GLI1和PTTG1水平高于无LNM患者。评估CRC患者LNM时GLI1和PTTG1的ROC曲线下面积分别为0.824和0.811。
结论：GLI1和PTTG1的表达在接受CRC根治术的患者中上调，并且在这些患者中与LNM显著相关。此外，高GLI1和PTTG1表达可提示接受根治性手术的CRC患者存在LNM.这两种基因的表达均具有一定的诊断和治疗意义。
