Abstract：
Prostatitis represents a common disease of the male genitourinary system, significantly impacting the physical and mental health of male patients. While numerous studies have suggested a potential link between immune cell activity and prostatitis, the exact causal role of immune cells in prostatitis remains uncertain. This study aims to explore the causal relationship between immune cell characteristics and prostatitis using a bidirectional Mendelian randomization approach. This study utilizes data from the public GWAS database and employs bidirectional Mendelian randomization analysis to investigate the causal relationship between immune cells and prostatitis. The causal relationship between 731 immune cell features and prostatitis was primarily investigated through inverse variance weighting (IVW), complemented by MR-Egger regression, a simple model, the weighted median method, and a weighted model. Ultimately, the results underwent sensitivity analysis to assess the heterogeneity, horizontal pleiotropy, and stability of Single Nucleotide Polymorphisms (SNPs) in immune cells and prostatitis. MR analysis revealed 17 immune cells exhibiting significant causal effects on prostatitis. In contrast, findings from reverse MR indicated a significant causal relationship between prostatitis and 13 immune cells. Our study utilizes bidirectional Mendelian Randomization to establish causal relationships between specific immune cell phenotypes and prostatitis, highlighting the reciprocal influence between immune system behavior and the disease. Our findings suggest targeted therapeutic approaches and the importance of including diverse populations for broader validation and personalized treatment strategies.
摘要：
前列腺炎代表男性泌尿生殖系统的常见疾病，显著影响男性患者的身心健康。虽然许多研究表明免疫细胞活性和前列腺炎之间存在潜在的联系，免疫细胞在前列腺炎中的确切因果作用仍不确定。本研究旨在使用双向孟德尔随机化方法探讨免疫细胞特征与前列腺炎之间的因果关系。本研究利用来自公共GWAS数据库的数据，并采用双向孟德尔随机化分析来研究免疫细胞与前列腺炎之间的因果关系。731免疫细胞特征与前列腺炎之间的因果关系主要通过方差逆加权(IVW)进行研究。辅以MR-Egger回归，一个简单的模型，加权中位数法，和加权模型。最终,结果进行了敏感性分析，以评估异质性，水平多效性，免疫细胞和前列腺炎中单核苷酸多态性（SNP）的稳定性。MR分析显示17个免疫细胞对前列腺炎表现出显著的因果效应。相比之下,反向MR的发现表明前列腺炎与13种免疫细胞之间存在显着因果关系。我们的研究利用双向孟德尔随机化建立特定免疫细胞表型和前列腺炎之间的因果关系，强调免疫系统行为和疾病之间的相互影响。我们的研究结果表明，有针对性的治疗方法以及纳入不同人群对更广泛的验证和个性化治疗策略的重要性。
