Abstract：
Organizing pneumonia, acute fibrinous and organizing pneumonia, and diffuse alveolar damage, represent multi-compartment patterns of lung injury. The initial region of injury in all remains the same and is centered on the fused basement membrane (BM) between the capillary endothelium and type I pneumocyte. Injury leads to cellular death, BM denudation, increased cellular permeability, and BM structural damage, which leads to exudation, organization, and attempts at repair. When acute lung injury does lead to fibrosis, in some instances it can lead to histologic and/or radiologic usual interstitial pneumonia or nonspecific interstital pneumonia patterns suggesting that lung injury is the primary mechanism for the development of fibrosis.
摘要：
机化肺炎,急性纤维性和机化性肺炎,弥漫性肺泡损伤,代表肺损伤的多房室模式。所有损伤的初始区域保持相同，并集中在毛细血管内皮和I型肺细胞之间的融合基底膜（BM）上。损伤导致细胞死亡,BM剥蚀,细胞通透性增加，和BM结构损坏，导致渗出，组织,并尝试修复。当急性肺损伤导致纤维化时，在某些情况下,它可导致组织学和/或放射学常见间质性肺炎或非特异性间质性肺炎模式,提示肺损伤是纤维化发展的主要机制.
