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Abstract：
BACKGROUND: 18Fluorine-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET) CT imaging has been used in many inflammatory and infectious conditions to differentiate areas of increased metabolic activity. FDG uptake differs between areas of normal lung parenchyma and interstitial lung disease (ILD).
OBJECTIVE: In this study, we investigated whether FDG-PET/CT parameters were associated with a change in the quality of life (QoL) in patients with ILD over 4 years of follow-up.
METHODS: Patients underwent PET-CT imaging at diagnosis and were followed up with annual QoL assessment using the St George\'s Respiratory Questionnaire (SGRQ) until death or 4 years of follow-up. Maximum standard uptake value (SUVmax) and Tissue-to-Background Ratio (TBR) were assessed against SGRQ overall and subscale scores.
RESULTS: 193 patients (94 patients in the idiopathic pulmonary fibrosis (IPF) subgroup and 99 patients in the non-IPF subgroup) underwent baseline FDG-PET/CT imaging and QoL assessment. Weak-to-moderate correlation was observed between baseline SUVmax and SGRQ scores in both ILD subgroups. No relationship was observed between baseline SUVmax or TBR and change in SGRQ scores over 4 years of follow-up. In the IPF subgroup, surviving patients reported a decline in QoL at 4 years post diagnosis whereas an improvement in QoL was seen in surviving patients with non-IPF ILD.
CONCLUSIONS: Weak-to-moderate positive correlation between baseline SUVmax and SGRQ scores was observed in both ILD subgroups (IPF:rs=0.187, p=0.047, non-IPF: rs=0.320, p=0.001). However, baseline SUVmax and TBR were not associated with change in QoL in patients with IPF and non-IPF ILD over 4 years of follow-up. At 4 years post diagnosis, surviving patients with IPF reported declining QoL whereas improvement was seen in patients with ILD who did not have IPF.
OBJECTIVE: In this study, we investigated whether FDG-PET/CT parameters were associated with a change in the quality of life (QoL) in patients with ILD over 4 years of follow-up.
METHODS: Patients underwent PET-CT imaging at diagnosis and were followed up with annual QoL assessment using the St George\'s Respiratory Questionnaire (SGRQ) until death or 4 years of follow-up. Maximum standard uptake value (SUVmax) and Tissue-to-Background Ratio (TBR) were assessed against SGRQ overall and subscale scores.
RESULTS: 193 patients (94 patients in the idiopathic pulmonary fibrosis (IPF) subgroup and 99 patients in the non-IPF subgroup) underwent baseline FDG-PET/CT imaging and QoL assessment. Weak-to-moderate correlation was observed between baseline SUVmax and SGRQ scores in both ILD subgroups. No relationship was observed between baseline SUVmax or TBR and change in SGRQ scores over 4 years of follow-up. In the IPF subgroup, surviving patients reported a decline in QoL at 4 years post diagnosis whereas an improvement in QoL was seen in surviving patients with non-IPF ILD.
CONCLUSIONS: Weak-to-moderate positive correlation between baseline SUVmax and SGRQ scores was observed in both ILD subgroups (IPF:rs=0.187, p=0.047, non-IPF: rs=0.320, p=0.001). However, baseline SUVmax and TBR were not associated with change in QoL in patients with IPF and non-IPF ILD over 4 years of follow-up. At 4 years post diagnosis, surviving patients with IPF reported declining QoL whereas improvement was seen in patients with ILD who did not have IPF.
摘要：
背景：18氟-氟脱氧葡萄糖（18F-FDG）正电子发射断层扫描（PET）CT成像已用于许多炎症和感染状况，以区分代谢活动增加的区域。FDG摄取在正常肺实质和间质性肺病(ILD)区域之间不同。
目的：在本研究中，我们调查了FDG-PET/CT参数是否与ILD患者4年随访期间的生活质量(QoL)变化相关.
方法：患者在诊断时接受PET-CT成像，并使用圣乔治呼吸问卷（SGRQ）进行年度QoL评估，直至死亡或随访4年。根据SGRQ总体和子量表评分评估最大标准摄取值（SUVmax）和组织背景比（TBR）。
结果：193例患者（特发性肺纤维化（IPF）亚组94例，非IPF亚组99例）接受了基线FDG-PET/CT成像和QoL评估。在两个ILD亚组中，基线SUVmax和SGRQ评分之间观察到弱至中度相关性。在4年的随访中，基线SUVmax或TBR与SGRQ评分变化之间未观察到相关性。在IPF分组中，存活患者在诊断后4年报告QoL下降,而存活的非IPFILD患者QoL改善.
结论：在两个ILD亚组中观察到基线SUVmax和SGRQ评分之间的弱至中度正相关（IPF：rs=0.187，p=0.047，非IPF：rs=0.320，p=0.001）。然而,基线SUVmax和TBR与IPF和非IPFILD患者在4年随访期间的QoL变化无关。诊断后4年，存活的IPF患者报告QoL下降,而无IPF的ILD患者QoL改善.
目的：在本研究中，我们调查了FDG-PET/CT参数是否与ILD患者4年随访期间的生活质量(QoL)变化相关.
方法：患者在诊断时接受PET-CT成像，并使用圣乔治呼吸问卷（SGRQ）进行年度QoL评估，直至死亡或随访4年。根据SGRQ总体和子量表评分评估最大标准摄取值（SUVmax）和组织背景比（TBR）。
结果：193例患者（特发性肺纤维化（IPF）亚组94例，非IPF亚组99例）接受了基线FDG-PET/CT成像和QoL评估。在两个ILD亚组中，基线SUVmax和SGRQ评分之间观察到弱至中度相关性。在4年的随访中，基线SUVmax或TBR与SGRQ评分变化之间未观察到相关性。在IPF分组中，存活患者在诊断后4年报告QoL下降,而存活的非IPFILD患者QoL改善.
结论：在两个ILD亚组中观察到基线SUVmax和SGRQ评分之间的弱至中度正相关（IPF：rs=0.187，p=0.047，非IPF：rs=0.320，p=0.001）。然而,基线SUVmax和TBR与IPF和非IPFILD患者在4年随访期间的QoL变化无关。诊断后4年，存活的IPF患者报告QoL下降,而无IPF的ILD患者QoL改善.
