Abstract：
BACKGROUND: Philadelphia chromosome-negative myeloproliferative neoplasms (Ph-negative MPNs) are linked with various complications, notably ischemic stroke. The study aims to identify risk factors for ischemic stroke in Ph-negative MPNs patients.
METHODS: Patients were categorized into two groups based on whether they had experienced ischemic stroke. Subsequently, an analysis of demographics, biochemical makers, and genetic mutations (JAK2V617F and CALR mutations), was conducted to identify potential associations with an elevated risk of ischemic stroke in individuals with Ph-negative MPNs.
RESULTS: A total of 185 patients diagnosed with Ph-negative MPNs participated in the study, including 82 with essential thrombocythemia (ET), 78 with polycythemia vera (PV), and 25 with primary myelofibrosis (PMF). Among these, 57 patients (30.8 %) had a history of ischemic stroke. Independent risk factors associated with ischemic stroke in Ph-negative MPNs patients included hypertension (OR = 5.076) and smoking (OR = 5.426). Among ET patients, smoking (OR = 4.114) and an elevated percentage of neutrophils (OR = 1.080) were both positively correlated with ischemic stroke incidence. For PV patients, hypertension (OR = 4.647), smoking (OR = 6.065), and an increased percentage of lymphocytes (OR = 1.039) were independently associated with ischemic stroke. Regardless of the presence of the JAK2V617F mutation, hypertension was the sole positively and independently associated risk factor for ischemic stroke. The odds ratios for patients with the JAK2V617F mutation was 3.103, while for those without the mutation, it was 11.25.
CONCLUSIONS: Hypertension was a more substantial factor associated with an increased incidence of ischemic stroke in Ph-negative MPNs patients.
METHODS: Patients were categorized into two groups based on whether they had experienced ischemic stroke. Subsequently, an analysis of demographics, biochemical makers, and genetic mutations (JAK2V617F and CALR mutations), was conducted to identify potential associations with an elevated risk of ischemic stroke in individuals with Ph-negative MPNs.
RESULTS: A total of 185 patients diagnosed with Ph-negative MPNs participated in the study, including 82 with essential thrombocythemia (ET), 78 with polycythemia vera (PV), and 25 with primary myelofibrosis (PMF). Among these, 57 patients (30.8 %) had a history of ischemic stroke. Independent risk factors associated with ischemic stroke in Ph-negative MPNs patients included hypertension (OR = 5.076) and smoking (OR = 5.426). Among ET patients, smoking (OR = 4.114) and an elevated percentage of neutrophils (OR = 1.080) were both positively correlated with ischemic stroke incidence. For PV patients, hypertension (OR = 4.647), smoking (OR = 6.065), and an increased percentage of lymphocytes (OR = 1.039) were independently associated with ischemic stroke. Regardless of the presence of the JAK2V617F mutation, hypertension was the sole positively and independently associated risk factor for ischemic stroke. The odds ratios for patients with the JAK2V617F mutation was 3.103, while for those without the mutation, it was 11.25.
CONCLUSIONS: Hypertension was a more substantial factor associated with an increased incidence of ischemic stroke in Ph-negative MPNs patients.
摘要：
背景：费城染色体阴性骨髓增殖性肿瘤（Ph阴性MPN）与各种并发症有关，尤其是缺血性中风。该研究旨在确定Ph阴性MPNs患者缺血性卒中的危险因素。
方法：根据患者是否经历过缺血性卒中，将患者分为两组。随后，人口统计学分析，生化制造商，和基因突变（JAK2V617F和CALR突变），本研究旨在确定Ph阴性MPN患者缺血性卒中风险升高的潜在关联。
结果：共有185名诊断为Ph阴性MPNs的患者参与了这项研究，包括82例原发性血小板增多症（ET），78例真性红细胞增多症（PV），25例原发性骨髓纤维化（PMF）。其中,57例(30.8%)患者有缺血性脑卒中病史。Ph阴性MPNs患者缺血性卒中的独立危险因素包括高血压(OR=5.076)和吸烟(OR=5.426)。在ET患者中，吸烟(OR=4.114)和中性粒细胞百分比升高(OR=1.080)均与缺血性卒中发生率呈正相关.对于PV患者，高血压（OR=4.647），吸烟（OR=6.065），淋巴细胞百分比增加(OR=1.039)与缺血性卒中独立相关。无论是否存在JAK2V617F突变，高血压是缺血性卒中唯一正相关且独立相关的危险因素.具有JAK2V617F突变的患者的比值比为3.103，而对于没有突变的患者，是11.25。
结论：高血压是与Ph阴性MPNs患者缺血性卒中发生率增加相关的更重要因素。
方法：根据患者是否经历过缺血性卒中，将患者分为两组。随后，人口统计学分析，生化制造商，和基因突变（JAK2V617F和CALR突变），本研究旨在确定Ph阴性MPN患者缺血性卒中风险升高的潜在关联。
结果：共有185名诊断为Ph阴性MPNs的患者参与了这项研究，包括82例原发性血小板增多症（ET），78例真性红细胞增多症（PV），25例原发性骨髓纤维化（PMF）。其中,57例(30.8%)患者有缺血性脑卒中病史。Ph阴性MPNs患者缺血性卒中的独立危险因素包括高血压(OR=5.076)和吸烟(OR=5.426)。在ET患者中，吸烟(OR=4.114)和中性粒细胞百分比升高(OR=1.080)均与缺血性卒中发生率呈正相关.对于PV患者，高血压（OR=4.647），吸烟（OR=6.065），淋巴细胞百分比增加(OR=1.039)与缺血性卒中独立相关。无论是否存在JAK2V617F突变，高血压是缺血性卒中唯一正相关且独立相关的危险因素.具有JAK2V617F突变的患者的比值比为3.103，而对于没有突变的患者，是11.25。
结论：高血压是与Ph阴性MPNs患者缺血性卒中发生率增加相关的更重要因素。
