Abstract：
In the past, the administration of medicines for children mainly involved changes to adult dosage forms, such as crushing tablets or opening capsules. However, these methods often led to inconsistent dosing, resulting in under- or overdosing. To address this problem and promote adherence, numerous initiatives, and regulatory frameworks have been developed to develop more child-friendly dosage forms. In recent years, multiparticulate dosage forms such as mini-tablets, pellets, and granules have gained popularity. However, a major challenge that persists is effectively masking the bitter taste of drugs in such formulations. This review therefore provides a brief overview of the current state of the art in taste masking techniques, with a particular focus on taste masking by film coating. Methods for evaluating the effectiveness of taste masking are also discussed and commented on. Another important issue that arises frequently in this area is achieving sufficient dissolution of poorly water-soluble drugs. Since the simultaneous combination of sufficient dissolution and taste masking is particularly challenging, the second objective of this review is to provide a critical summary of studies dealing with multiparticulate formulations that are tackling both of these issues.
摘要：
在过去,儿童用药主要涉及成人剂型的改变，如压碎片剂或打开胶囊。然而,这些方法通常导致剂量不一致，导致剂量不足或过量。为解决这一问题,促进坚持,众多举措,并制定了监管框架，以开发更多对儿童友好的剂型。近年来,多颗粒剂型，如迷你片剂，颗粒,和颗粒已经普及。然而,持续存在的主要挑战是有效地掩盖此类制剂中药物的苦味。因此，这篇综述简要概述了掩味技术的现状，特别注重通过薄膜包衣掩盖味道。还讨论并评论了评估掩味效果的方法。在该领域中经常出现的另一个重要问题是实现水溶性差的药物的充分溶解。由于充分溶解和掩味的同时结合特别具有挑战性，本综述的第二个目的是对处理这两个问题的多颗粒制剂的研究进行重要总结.
