Abstract：
Osteoarthritis (OA) is one of the leading causes of joint dysfunction and disability in the elderly, posing serious social problems and a huge socio-economic burden. Existing pharmacological treatments have significant drawbacks, and searching for an effective pharmacological intervention is an urgent priority. Recent studies have demonstrated the chondroprotective, anabolic, and anti-catabolic properties of avocado-soybean unsaponifiable (ASU), a natural plant extract made from avocado and soybean oils, consisting of the remainder of the saponified portion of the product that cannot be made into soap. The main components of ASU are phytosterols, beta-sitosterol, canola stanols, and soya stanols, which are rapidly incorporated into cells. Studies have confirmed the anti-inflammatory, antioxidant, and analgesic properties of phytosterols. ASU slows down the progression of OA primarily by inhibiting pathways involved in the development of OA disease. ASU prevents cartilage degradation by inhibiting the release and activity of matrix metalloproteinases and by increasing the tissue inhibition of these catabolic enzymes; ASU is also involved in the inhibition of the activation of nuclear factor κB (NF-κB) which is a transcriptional inhibitor that regulates the inflammatory response of chondrocytes. NF-κB is a transcription factor that regulates the inflammatory response of chondrocytes, and inhibition of the transfer of the transcription factor NF-κB from the cytoplasm to the nucleus regulates the transcription of many pro-inflammatory factors. By appealing to the mechanism of action and thus achieving anti-inflammatory, anti-catabolic, and pro-synthetic effects on cartilage tissues, AUS is clinically responsive to the reduction of acute pain and OA symptom progression. This paper aims to summarize the studies on the use of avocado-soybean unsaponifiable in the pharmacological treatment of osteoarticular.
摘要：
骨关节炎(OA)是导致老年人关节功能障碍和残疾的主要原因之一,造成严重的社会问题和巨大的社会经济负担。现有的药物治疗具有显著的缺点，寻找有效的药物干预是当务之急。最近的研究表明软骨保护，合成代谢,鳄梨-大豆不皂化物（ASU）的抗分解代谢特性，由鳄梨和大豆油制成的天然植物提取物，由不能制成肥皂的产品的皂化部分的其余部分组成。ASU的主要成分是植物甾醇，β-谷甾醇,油菜甾烷醇,还有大豆甾烷,迅速融入细胞。研究证实了抗炎，抗氧化剂，和植物甾醇的镇痛特性。ASU主要通过抑制参与OA疾病发展的途径来减缓OA的进展。ASU通过抑制基质金属蛋白酶的释放和活性以及通过增加这些分解代谢酶的组织抑制来防止软骨降解；ASU还参与抑制核因子κB（NF-κB）的激活，NF-κB是调节软骨细胞炎症反应的转录抑制剂。NF-κB是调节软骨细胞炎症反应的转录因子,转录因子NF-κB从细胞质转移到细胞核的抑制调节了许多促炎因子的转录。通过呼吁作用机制，从而实现抗炎，抗分解代谢，和对软骨组织的促合成作用，AUS在临床上对急性疼痛和OA症状进展的减少有反应。本文旨在总结鳄梨-大豆不皂化物在骨关节的药物治疗中的研究。
