PDF(Pubmed)
Abstract：
The placenta plays a crucial role in maintaining normal pregnancy. The failure of spiral artery remodeling (SAR) is a key factor leading to placental ischemia and poor perfusion which is strongly associated with obstetric diseases, including preeclampsia (PE) and fetal growth restriction (FGR). Existing interventions for PE and FGR are limited and termination of pregnancy is inevitable when the maternal or fetus condition deteriorates. Considering the safety of the mother and fetus, treatments that may penetrate the placental barrier and harm the fetus are not accepted. Developing targeted treatment strategies for these conditions is urgent and necessary. With the proven efficacy of targeted therapy in treating conditions such as endometrial cancer and trophoblastic tumors, research on placental dysfunction continues to deepen. This article reviews the studies on placenta-targeted treatment and drug delivery strategies, summarizes the characteristics proposes corresponding improvement measures in targeted treatment, provides solutions for existing problems, and makes suggestions for future studies.
摘要：
胎盘在维持正常妊娠中起着至关重要的作用。螺旋动脉重构（SAR）失败是导致胎盘缺血和灌注不良的关键因素，与产科疾病密切相关。包括先兆子痫（PE）和胎儿生长受限（FGR）。对于PE和FGR的现有干预措施是有限的,并且当母体或胎儿病情恶化时终止妊娠是不可避免的。考虑到母亲和胎儿的安全，不接受可能穿透胎盘屏障并伤害胎儿的治疗。针对这些情况制定有针对性的治疗策略是紧迫和必要的。随着靶向疗法在治疗子宫内膜癌和滋养细胞肿瘤等疾病方面的有效性，对胎盘功能障碍的研究不断深入。本文就胎盘靶向治疗及给药策略的研究进行综述,特点总结,在针对性治疗中提出相应的改进措施,为现有问题提供解决方案，并对未来的研究提出建议。
