Abstract：
UNASSIGNED: To analyze the referral patterns and the clinical and therapeutic features of patients diagnosed with uveitis in an Italian tertiary referral center to provide a comparison with previously published series from the same center.
UNASSIGNED: Retrospective retrieval of data on all new referrals to the Ocular Immunology Unit in Reggio Emilia (Italy) between November 2015 and April 2022 and comparison with previously published series from the same center.
UNASSIGNED: Among the 1557 patients, the male-to-female ratio was 1:1.27. Anterior uveitis was the most common diagnosis (53.7%), followed by posterior (21.6%), pan- (18.5%), and intermediate (6.2%) uveitis. The most identifiable specific diagnoses were anterior herpetic uveitis (18.4%), Fuchs uveitis (12.8%), and tuberculosis (6.1%). Infectious etiologies were the most frequent (34.1%) and were more diffuse among non-Caucasian patients (p < 0.001), followed by systemic disease-associated uveitis (26.5%), and ocular-specific conditions (20%). Idiopathic uveitis accounted for 19.4% of cases. Fuchs uveitis presented the longest median diagnostic delay (21 months). Immunosuppressants were administered to 25.2% of patients. Antimetabolites, calcineurin inhibitors, and biologicals were prescribed to 18.4%, 3%, and 11.4% of cases, respectively. Compared to our previous reports, we observed a significant increase in foreign-born patients and in infectious uveitis, a decrease in idiopathic conditions, and an increasing use of non-biological and biological steroid-sparing drugs.
UNASSIGNED: The patterns of uveitis in Italy have been changing over the last 20 years, very likely due to migration flows. Diagnostic improvements and a more widespread interdisciplinary approach could reduce the incidence of idiopathic uveitis as well as diagnostic delay.
UNASSIGNED: Retrospective retrieval of data on all new referrals to the Ocular Immunology Unit in Reggio Emilia (Italy) between November 2015 and April 2022 and comparison with previously published series from the same center.
UNASSIGNED: Among the 1557 patients, the male-to-female ratio was 1:1.27. Anterior uveitis was the most common diagnosis (53.7%), followed by posterior (21.6%), pan- (18.5%), and intermediate (6.2%) uveitis. The most identifiable specific diagnoses were anterior herpetic uveitis (18.4%), Fuchs uveitis (12.8%), and tuberculosis (6.1%). Infectious etiologies were the most frequent (34.1%) and were more diffuse among non-Caucasian patients (p < 0.001), followed by systemic disease-associated uveitis (26.5%), and ocular-specific conditions (20%). Idiopathic uveitis accounted for 19.4% of cases. Fuchs uveitis presented the longest median diagnostic delay (21 months). Immunosuppressants were administered to 25.2% of patients. Antimetabolites, calcineurin inhibitors, and biologicals were prescribed to 18.4%, 3%, and 11.4% of cases, respectively. Compared to our previous reports, we observed a significant increase in foreign-born patients and in infectious uveitis, a decrease in idiopathic conditions, and an increasing use of non-biological and biological steroid-sparing drugs.
UNASSIGNED: The patterns of uveitis in Italy have been changing over the last 20 years, very likely due to migration flows. Diagnostic improvements and a more widespread interdisciplinary approach could reduce the incidence of idiopathic uveitis as well as diagnostic delay.
摘要：
■分析在意大利三级转诊中心诊断为葡萄膜炎的患者的转诊模式以及临床和治疗特征，以提供与该中心先前发表的系列比较。
回顾性检索2015年11月至2022年4月期间所有新转诊到雷焦艾米利亚（意大利）眼免疫学部门的数据，并与同一中心先前发布的系列进行比较。
■在1557名患者中，男女比例为1:1.27.前葡萄膜炎是最常见的诊断（53.7%），其次是后(21.6%)，pan-（18.5%），和中度(6.2%)葡萄膜炎。最明显的特异性诊断是前疱疹性葡萄膜炎（18.4%），Fuchs葡萄膜炎（12.8%），和结核病（6.1%）。在非白种人患者中，感染病因最常见(34.1%)，且更为弥漫性(p<0.001)。其次是全身性疾病相关葡萄膜炎（26.5%），和眼部特定条件（20％）。特发性葡萄膜炎占病例的19.4%。Fuchs葡萄膜炎的中位诊断延迟最长（21个月）。对25.2%的患者施用免疫抑制剂。抗代谢物，钙调磷酸酶抑制剂，生物制品被规定为18.4%，3%,和11.4%的病例，分别。与我们以前的报告相比，我们观察到外国出生的患者和感染性葡萄膜炎显著增加，特发性疾病的减少，以及越来越多地使用非生物和生物类固醇药物。
■在过去的20年里，意大利葡萄膜炎的模式一直在改变，很可能是由于移民流动。诊断改进和更广泛的跨学科方法可以减少特发性葡萄膜炎的发生率以及诊断延迟。
回顾性检索2015年11月至2022年4月期间所有新转诊到雷焦艾米利亚（意大利）眼免疫学部门的数据，并与同一中心先前发布的系列进行比较。
■在1557名患者中，男女比例为1:1.27.前葡萄膜炎是最常见的诊断（53.7%），其次是后(21.6%)，pan-（18.5%），和中度(6.2%)葡萄膜炎。最明显的特异性诊断是前疱疹性葡萄膜炎（18.4%），Fuchs葡萄膜炎（12.8%），和结核病（6.1%）。在非白种人患者中，感染病因最常见(34.1%)，且更为弥漫性(p<0.001)。其次是全身性疾病相关葡萄膜炎（26.5%），和眼部特定条件（20％）。特发性葡萄膜炎占病例的19.4%。Fuchs葡萄膜炎的中位诊断延迟最长（21个月）。对25.2%的患者施用免疫抑制剂。抗代谢物，钙调磷酸酶抑制剂，生物制品被规定为18.4%，3%,和11.4%的病例，分别。与我们以前的报告相比，我们观察到外国出生的患者和感染性葡萄膜炎显著增加，特发性疾病的减少，以及越来越多地使用非生物和生物类固醇药物。
■在过去的20年里，意大利葡萄膜炎的模式一直在改变，很可能是由于移民流动。诊断改进和更广泛的跨学科方法可以减少特发性葡萄膜炎的发生率以及诊断延迟。
