Abstract：
Poultry products are an important source of foodborne Salmonella infections in humans. Amongst these, the prevalence of S. Infantis is rising. In this study, the protection efficacy of an authorized live-attenuated S. Typhimurium vaccine against S. Infantis, was examined using a seeder-bird model in broilers. Vaccinated birds displayed a significantly lower colonization of S. Infantis bacteria in the caeca compared to the non-vaccinated counterparts (P = 0.017), with no significant differences observed in the spleen among the groups, three days post-infection. Thirty-two days post-infection, the disparity in average S. Infantis concentration between all-vaccinated and non-vaccinated birds was significant in both caeca (P = 0.0003) and spleen (P = 0.0002). Interestingly, a third group, consisting of seeder birds that were not vaccinated but housed with vaccinated penmates, exhibited significantly lower S. Infantis levels in both caeca (P = 0.0014) and spleen (P < 0.0001) compared to the non-vaccinated group. These findings underscore the potential of a live-attenuated S. Typhimurium vaccine administered to 2-day-old chicks in conferring protection against S. Infantis in broilers up to slaughter age.
摘要：
家禽产品是人类食源性沙门氏菌感染的重要来源。其中,婴儿链球菌的患病率正在上升。在这项研究中，授权的减毒鼠伤寒沙门氏菌活疫苗对婴儿沙门氏菌的保护效力，在肉鸡中使用播种鸟模型进行了检查。与未接种疫苗的鸟类相比，接种疫苗的鸟类在盲肠中的婴儿链球菌定植显着降低（p=0.017），各组之间在脾脏中没有观察到显著差异，感染后三天。感染后32天,在盲肠(p=0.0003)和脾脏(p=0.0002)中,所有接种疫苗的禽类和未接种疫苗的禽类之间的平均婴儿链球菌浓度差异显著.有趣的是,第三组,由未接种疫苗但饲养接种疫苗的雏鸟组成，与未接种组相比,在盲肠(p=0.0014)和脾(p<0.0001)中表现出显著更低的婴儿链球菌水平。这些发现强调了向2天大的雏鸡施用的减毒鼠伤寒沙门氏菌活疫苗在直到屠宰年龄的肉鸡中赋予针对婴儿链球菌的保护的潜力。
