PDF(Pubmed)
Abstract：
UNASSIGNED: Aspiration pneumonia (AP) challenges public health globally. The primary aim of this study was to ascertain the microbiological profile characteristics of patients with AP evaluated by combined detection methods, including conventional microbiological tests (CMTs), chips for complicated infection detection (CCID), and metagenomic next-generation sequencing (mNGS).
UNASSIGNED: From June 2021 to March 2022, a total of thirty-nine patients with AP or community-acquired pneumonia with aspiration risk factors (AspRF-CAP) from 3 hospitals were included. Respiratory specimens, including bronchoalveolar lavage fluid (BALF), sputum, and tracheal aspirate, were collected for microorganism detection.
UNASSIGNED: Patients with AP were more inclined to be older, to have a shorter duration from illness onset to admission, to have a higher prevalence of different underlying diseases, particularly diabetes mellitus, chronic heart disease, and cerebrovascular disease, and to have a higher CURB-65 score (all P < 0.05). A total of 213 and 31 strains of microorganisms were detected in patients with AP and AspRF-CAP, respectively. The most common pathogens in AP were Corynebacterium striatum (17/213, 7.98%), Pseudomonas aeruginosa (15/213, 7.04%), Klebsiella pneumoniae (15/213, 7.04%), and Candida albicans (14/213, 6.57%). Besides, the most common pathogens in AspRF-CAP were Candida albicans (5/31, 16.13%), Pseudomonas aeruginosa (3/31, 9.68%) and Klebsiella pneumoniae (3/31, 9.68%). Moreover, Klebsiella pneumoniae (7/67, 10.45%) and Candida glabrata (5/67, 7.46%) were the most common pathogens among the 9 non-survived patients with AP.
UNASSIGNED: The prevalent pathogens detected in cases of AP were Corynebacterium striatum, Pseudomonas aeruginosa, Klebsiella pneumoniae, and Candida albicans. Early combined detection methods for patients with AP enhance the positive detection rate of pathogens and potentially expedites the initiation of appropriate antibiotic therapeutic strategies.
UNASSIGNED: From June 2021 to March 2022, a total of thirty-nine patients with AP or community-acquired pneumonia with aspiration risk factors (AspRF-CAP) from 3 hospitals were included. Respiratory specimens, including bronchoalveolar lavage fluid (BALF), sputum, and tracheal aspirate, were collected for microorganism detection.
UNASSIGNED: Patients with AP were more inclined to be older, to have a shorter duration from illness onset to admission, to have a higher prevalence of different underlying diseases, particularly diabetes mellitus, chronic heart disease, and cerebrovascular disease, and to have a higher CURB-65 score (all P < 0.05). A total of 213 and 31 strains of microorganisms were detected in patients with AP and AspRF-CAP, respectively. The most common pathogens in AP were Corynebacterium striatum (17/213, 7.98%), Pseudomonas aeruginosa (15/213, 7.04%), Klebsiella pneumoniae (15/213, 7.04%), and Candida albicans (14/213, 6.57%). Besides, the most common pathogens in AspRF-CAP were Candida albicans (5/31, 16.13%), Pseudomonas aeruginosa (3/31, 9.68%) and Klebsiella pneumoniae (3/31, 9.68%). Moreover, Klebsiella pneumoniae (7/67, 10.45%) and Candida glabrata (5/67, 7.46%) were the most common pathogens among the 9 non-survived patients with AP.
UNASSIGNED: The prevalent pathogens detected in cases of AP were Corynebacterium striatum, Pseudomonas aeruginosa, Klebsiella pneumoniae, and Candida albicans. Early combined detection methods for patients with AP enhance the positive detection rate of pathogens and potentially expedites the initiation of appropriate antibiotic therapeutic strategies.
摘要：
■吸入性肺炎（AP）挑战全球公共卫生。这项研究的主要目的是确定通过联合检测方法评估的AP患者的微生物学特征，包括常规微生物测试（CMT），复杂感染检测芯片（CCID），和宏基因组下一代测序（mNGS）。
■从2021年6月至2022年3月，共有来自3家医院的39例AP或具有吸入性危险因素的社区获得性肺炎（AspRF-CAP）患者被纳入。呼吸道标本,包括支气管肺泡灌洗液（BALF），痰,和气管抽吸物,收集用于微生物检测。
■AP患者更倾向于年龄较大，从发病到入院的持续时间较短，不同基础疾病的患病率更高，特别是糖尿病，慢性心脏病,和脑血管疾病，CURB-65评分较高(均P<0.05)。在AP和AspRF-CAP患者中共检测到213株和31株微生物,分别。最常见的病原菌为纹状体棒状杆菌(17/213,7.98%),铜绿假单胞菌(15/213,7.04%),肺炎克雷伯菌（15/213，7.04%），白色念珠菌(14/213,6.57%)。此外,AspRF-CAP中最常见的病原菌为白色念珠菌(5/31,16.13%),铜绿假单胞菌(3/31,9.68%)和肺炎克雷伯菌(3/31,9.68%)。此外，肺炎克雷伯菌（7/67，10.45％）和光滑念珠菌（5/67，7.46％）是9例非存活AP患者中最常见的病原体。
■在AP病例中检测到的流行病原体是纹状体棒杆菌，铜绿假单胞菌,肺炎克雷伯菌,和白色念珠菌.AP患者的早期联合检测方法可提高病原体的阳性检测率，并可能加快启动适当的抗生素治疗策略。
■从2021年6月至2022年3月，共有来自3家医院的39例AP或具有吸入性危险因素的社区获得性肺炎（AspRF-CAP）患者被纳入。呼吸道标本,包括支气管肺泡灌洗液（BALF），痰,和气管抽吸物,收集用于微生物检测。
■AP患者更倾向于年龄较大，从发病到入院的持续时间较短，不同基础疾病的患病率更高，特别是糖尿病，慢性心脏病,和脑血管疾病，CURB-65评分较高(均P<0.05)。在AP和AspRF-CAP患者中共检测到213株和31株微生物,分别。最常见的病原菌为纹状体棒状杆菌(17/213,7.98%),铜绿假单胞菌(15/213,7.04%),肺炎克雷伯菌（15/213，7.04%），白色念珠菌(14/213,6.57%)。此外,AspRF-CAP中最常见的病原菌为白色念珠菌(5/31,16.13%),铜绿假单胞菌(3/31,9.68%)和肺炎克雷伯菌(3/31,9.68%)。此外，肺炎克雷伯菌（7/67，10.45％）和光滑念珠菌（5/67，7.46％）是9例非存活AP患者中最常见的病原体。
■在AP病例中检测到的流行病原体是纹状体棒杆菌，铜绿假单胞菌,肺炎克雷伯菌,和白色念珠菌.AP患者的早期联合检测方法可提高病原体的阳性检测率，并可能加快启动适当的抗生素治疗策略。
