PDF(Pubmed)
Abstract：
Cytomegalovirus (CMV) is the most common cause of congenital infection internationally, occurring in 0.67% of births, and increasingly recognised as a major public health burden due to the potential for long-term neurodevelopmental and hearing impairment. This burden includes estimates of 10% of childhood cerebral palsy and up to 25% of childhood deafness. In Sub-Saharan Africa, where CMV-seroprevalence is almost ubiquitous, prevalence of congenital CMV (cCMV) is higher than the global average, and yet there is a dearth of research and initiatives to improve recognition, diagnosis and treatment. This narrative review outlines the epidemiology and clinical presentation of cCMV, discusses issues of case identification and treatment in Sub-Saharan Africa, and recommends a framework of strategies to address these challenges. Considering the significant burden of cCMV disease in this setting, it is undoubtably time we embark upon improving diagnosis and care for these infants.
摘要：
巨细胞病毒（CMV）是国际上最常见的先天性感染原因，发生在0.67%的新生儿中，并且由于长期神经发育和听力损害的潜力，越来越被认为是主要的公共卫生负担。这种负担包括估计10％的儿童脑瘫和高达25％的儿童耳聋。在撒哈拉以南非洲，CMV血清阳性率几乎无处不在，先天性CMV(cCMV)患病率高于全球平均水平,然而，缺乏提高认可度的研究和举措，诊断和治疗。这篇叙述性综述概述了cCMV的流行病学和临床表现，讨论了撒哈拉以南非洲的病例识别和治疗问题，并提出了应对这些挑战的战略框架。考虑到在这种情况下cCMV疾病的重大负担，毫无疑问，现在是我们着手改善这些婴儿的诊断和护理的时候了。
