PDF(Pubmed)
Abstract：
Fewer than 26 case reports describe hypertrophic lichen planus (HLP) misdiagnosed as cutaneous squamous cell carcinoma (cSCC). It can be difficult to distinguish between HLP and cSCC, as these two conditions share many clinical and histopathological characteristics. Patients who are misdiagnosed with cSCC often undergo unnecessary medical and/or surgical interventions before receiving a diagnosis of HLP and improving on HLP-directed therapy. This case series highlights the course of three female patients, referred to a single tertiary institution between 2018 and 2022, who were initially misdiagnosed with cSCC before receiving a diagnosis of HLP. We have emphasized the clinical and histopathological distinguishing features between HLP and cSCC, the pathogenesis of HLP, and current and new HLP-directed therapy. We hope that this case series serves as a reminder to dermatologists, dermatologic surgeons, and dermatopathologists to be aware of this diagnostic challenge.
摘要：
不到26例报告描述了肥厚性扁平苔藓（HLP）误诊为皮肤鳞状细胞癌（cSCC）。很难区分HLP和cSCC，因为这两种情况具有许多临床和组织病理学特征。被误诊为cSCC的患者在接受HLP诊断并改善HLP定向治疗之前，通常会经历不必要的医疗和/或手术干预。这个病例系列突出了三名女性患者的病程，在2018年至2022年期间,转诊至一家大专院校,该院校最初在接受HLP诊断之前被误诊为cSCC.我们强调了HLP和cSCC的临床和组织病理学特征，HLP的发病机制，以及当前和新的HLP定向疗法。我们希望这个病例系列能提醒皮肤科医生，皮肤科医生,和皮肤病理学家意识到这一诊断挑战。
