关键词: Pharmacological Phytochemistry Safety Tinospora cordifolia Tinospora species (Menispermaceae) Toxicity

来  源:   DOI:10.1016/j.heliyon.2024.e31229   PDF(Pubmed)

Abstract:
Clinical investigations are increasingly focusing on natural materials with medical benefits because, in contrast to medicines, they have extremely few adverse effects. Tinospora species of the Menispermaceae family has many bioactive principles for plant nutraceuticals. A thorough assessment of the existing literature revealed that Indian Tinospora species are an important group of medicinal herbs used for a variety of pharmacological activities. While, Tinospora cordifolia is widely recognized as a significant herb in the Indian System of Medicines (ISM) due to its bioactive components and has been used in the treatment of diabetes, cancer, urinary problems, fever, jaundice, helminthiasis, leprosy, dysentery, skin diseases, and many more. Using the search phrases \"phytochemistry,\" \"traditional uses,\" and \"pharmacological evaluation of Indian Tinospora species,\" appropriate articles were carefully extracted from the MEDLINE/PubMed, Scopus, and WOS databases. Around 180 articles, related to the India Tinospora species, were selected from a pool of 200 papers published between 1991 and 2023. T. cordifolia has received a lot of scientific attention because of its diverse therapeutic characteristics in treating various diseases. Our present study in this review encompasses 1.) Phytochemistry, traditional uses and pharmacological potential of T. cordifolia as well as other Indian Tinospora species. 2.) Safety and toxicity study and available marketed formulation of T. cordifolia for the treatment of various diseases. The chemical constitution and pharmacological characteristics of other Tinospora species must also be investigated, indicating a need for further scientific research.
摘要:
临床研究越来越关注具有医疗益处的天然材料,因为,与药物相比,它们几乎没有副作用。Menispermaceae家族的Tinospora物种具有许多植物营养食品的生物活性原理。对现有文献的全面评估表明,印度Tinospora物种是用于多种药理活性的重要草药。同时,Tinosporacordifolia由于其生物活性成分而被广泛认为是印度药物系统(ISM)中的重要草药,并已用于治疗糖尿病。癌症,泌尿问题,发烧,黄疸,蠕虫病,麻风病,痢疾,皮肤病,还有更多。使用搜索短语“植物化学”,传统用途,印度Tinospora物种的“和”药理学评估,“从MEDLINE/PubMed中仔细提取了适当的文章,Scopus,WOS数据库。180篇文章与印度Tinospora物种有关,从1991年至2023年发表的200篇论文中选出。由于其在治疗各种疾病方面具有多样化的治疗特性,因此受到了许多科学关注。我们目前的研究包括1。)植物化学,传统用途和药理作用,以及其他印度Tinospora物种。2.)安全性和毒性研究以及可用于治疗各种疾病的T.cordifolia的市售制剂。还必须研究其他Tinospora物种的化学成分和药理特性,表明需要进一步的科学研究。
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