PDF(Pubmed)
Abstract：
BACKGROUND: Long COVID syndrome, characterized by symptoms like dyspnea, fatigue, and cough, persisting for weeks to months after the initial SARS-CoV-2 infection, poses significant challenges globally. Studies suggest a potential higher risk among females aged 40-50, with symptoms affecting individuals regardless of initial COVID-19 severity, underscoring the need for comprehensive understanding and management.
METHODS: A prospective longitudinal study was conducted at a teaching tertiary care institute in Central India, involving COVID-19 patients from May 2020 to September 2021. Participants, aged 18 or older, diagnosed with COVID-19 and surviving until the last follow-up, were monitored telephonically and during outpatient visits for treatment details and outcomes. Data analysis was done using R software 4.2.1.
RESULTS: The baseline characteristics of the study participants showed a majority of moderate COVID-19 severity (47.5%), with a higher proportion of males (64.8%) affected. Common comorbidities included diabetes (27.1%) and hypertension (22.9%). Long COVID-19 symptoms, notably breathlessness, were prevalent, with females exhibiting a significantly higher association. Pulmonary function abnormalities were associated with both long COVID-19 symptoms and higher COVID-19 severity categories, indicating lasting respiratory impact post-infection.
CONCLUSIONS: Long after the pandemic, COVID-19 continues to raise concerns due to persistent sequelae, with a majority experiencing long COVID symptoms, particularly those with severe initial illness, including breathlessness and abnormal lung function, highlighting prevalent restrictive lung pattern changes.
METHODS: A prospective longitudinal study was conducted at a teaching tertiary care institute in Central India, involving COVID-19 patients from May 2020 to September 2021. Participants, aged 18 or older, diagnosed with COVID-19 and surviving until the last follow-up, were monitored telephonically and during outpatient visits for treatment details and outcomes. Data analysis was done using R software 4.2.1.
RESULTS: The baseline characteristics of the study participants showed a majority of moderate COVID-19 severity (47.5%), with a higher proportion of males (64.8%) affected. Common comorbidities included diabetes (27.1%) and hypertension (22.9%). Long COVID-19 symptoms, notably breathlessness, were prevalent, with females exhibiting a significantly higher association. Pulmonary function abnormalities were associated with both long COVID-19 symptoms and higher COVID-19 severity categories, indicating lasting respiratory impact post-infection.
CONCLUSIONS: Long after the pandemic, COVID-19 continues to raise concerns due to persistent sequelae, with a majority experiencing long COVID symptoms, particularly those with severe initial illness, including breathlessness and abnormal lung function, highlighting prevalent restrictive lung pattern changes.
摘要：
背景：长型COVID综合征，以呼吸困难等症状为特征，疲劳,咳嗽,在首次感染SARS-CoV-2后持续数周至数月，在全球范围内构成重大挑战。研究表明，在40-50岁的女性中，潜在的风险更高，无论最初的COVID-19严重程度如何，症状都会影响个体，强调需要全面理解和管理。
方法：在印度中部的教学三级保健机构进行了一项前瞻性纵向研究，涉及2020年5月至2021年9月的COVID-19患者。参与者,18岁或以上，诊断为COVID-19并存活到最后一次随访，在电话和门诊就诊期间对治疗细节和结果进行监测.使用R软件4.2.1进行数据分析。
结果：研究参与者的基线特征显示大多数为中度COVID-19严重程度（47.5％），受影响的男性比例较高(64.8%)。常见的合并症包括糖尿病（27.1%）和高血压（22.9%）。长COVID-19症状，尤其是呼吸困难，普遍存在，女性表现出明显更高的关联性。肺功能异常与长期COVID-19症状和较高COVID-19严重程度类别相关，表明感染后持续的呼吸道影响。
结论：大流行后很久，由于持续的后遗症，COVID-19继续引起人们的关注，大多数人都有长期的COVID症状，特别是那些患有严重初始疾病的人，包括呼吸困难和肺功能异常，突出普遍的限制性肺部模式变化。
方法：在印度中部的教学三级保健机构进行了一项前瞻性纵向研究，涉及2020年5月至2021年9月的COVID-19患者。参与者,18岁或以上，诊断为COVID-19并存活到最后一次随访，在电话和门诊就诊期间对治疗细节和结果进行监测.使用R软件4.2.1进行数据分析。
结果：研究参与者的基线特征显示大多数为中度COVID-19严重程度（47.5％），受影响的男性比例较高(64.8%)。常见的合并症包括糖尿病（27.1%）和高血压（22.9%）。长COVID-19症状，尤其是呼吸困难，普遍存在，女性表现出明显更高的关联性。肺功能异常与长期COVID-19症状和较高COVID-19严重程度类别相关，表明感染后持续的呼吸道影响。
结论：大流行后很久，由于持续的后遗症，COVID-19继续引起人们的关注，大多数人都有长期的COVID症状，特别是那些患有严重初始疾病的人，包括呼吸困难和肺功能异常，突出普遍的限制性肺部模式变化。
