UNASSIGNED: This is a retrospective multicenter cross-sectional study of pediatric patients diagnosed with CNO. A total of 87 patients with a diagnosis of CNO followed for at least 6 months in 8 pediatric rheumatology centers across the country between January 2010 and December 2021 were included in this study.
UNASSIGNED: The study included 87 patients (38 girls, 49 boys; median age: 12.5 years). The median follow-up time was 20 months (IQR: 8.5-40). The median time of diagnostic delay was 9.9 months (IQR: 3-24). Arthralgia and bone pain were the most common presenting symptoms. Multifocal involvement was detected in 86.2% of the cases and a recurrent course was reported in one-third of those included in the study. The most commonly involved bones were the femur and tibia. Vertebrae and clavicles were affected in 19.5% and 20.6% of cases, respectively. The erythrocyte sedimentation rate (ESR) values of 60.9% of the patients were above 20 mm/h and the C-reactive protein values of 44.8% were above 5 mg/L. The remission rate was 13.3% in patients using nonsteroidal antiinflammatory drugs and 75.0% in those using biological drugs. Vertebral and mandibular involvement and high ESR values at the time of diagnosis were associated with recurrence.
UNASSIGNED: In this multicenter study, CNO with vertebral and mandibular involvement and high ESR at diagnosis were associated with recurrence.
■这是一项针对诊断为CNO的儿科患者的回顾性多中心横断面研究。本研究纳入了2010年1月至2021年12月间在全国8个儿科风湿病中心随访至少6个月的87例诊断为CNO的患者。
■该研究包括87名患者(38名女孩,49名男孩;平均年龄:12.5岁)。中位随访时间为20个月(IQR:8.5-40)。诊断延迟的中位时间为9.9个月(IQR:3-24)。关节痛和骨痛是最常见的症状。在86.2%的病例中检测到多灶性受累,并且在研究中的三分之一报告了复发过程。最常见的骨骼是股骨和胫骨。分别有19.5%和20.6%的病例影响脊椎和锁骨,分别。60.9%的患者血沉(ESR)值大于20mm/h,44.8%的患者C反应蛋白值大于5mg/L。使用非甾体抗炎药的患者缓解率为13.3%,使用生物药的患者缓解率为75.0%。脊椎和下颌骨受累以及诊断时的高ESR值与复发有关。
■在这项多中心研究中,CNO伴有椎体和下颌骨受累以及诊断时的高ESR与复发有关。