PDF(Pubmed)
Abstract：
UNASSIGNED: Chronic nonbacterial osteomyelitis (CNO) is a rare disease of unknown etiology and most commonly occurs during childhood or adolescence. The purpose of this study is to collect data on the clinical features, outcomes, and management of the disease and to identify the factors affecting recurrence.
UNASSIGNED: This is a retrospective multicenter cross-sectional study of pediatric patients diagnosed with CNO. A total of 87 patients with a diagnosis of CNO followed for at least 6 months in 8 pediatric rheumatology centers across the country between January 2010 and December 2021 were included in this study.
UNASSIGNED: The study included 87 patients (38 girls, 49 boys; median age: 12.5 years). The median follow-up time was 20 months (IQR: 8.5-40). The median time of diagnostic delay was 9.9 months (IQR: 3-24). Arthralgia and bone pain were the most common presenting symptoms. Multifocal involvement was detected in 86.2% of the cases and a recurrent course was reported in one-third of those included in the study. The most commonly involved bones were the femur and tibia. Vertebrae and clavicles were affected in 19.5% and 20.6% of cases, respectively. The erythrocyte sedimentation rate (ESR) values of 60.9% of the patients were above 20 mm/h and the C-reactive protein values of 44.8% were above 5 mg/L. The remission rate was 13.3% in patients using nonsteroidal antiinflammatory drugs and 75.0% in those using biological drugs. Vertebral and mandibular involvement and high ESR values at the time of diagnosis were associated with recurrence.
UNASSIGNED: In this multicenter study, CNO with vertebral and mandibular involvement and high ESR at diagnosis were associated with recurrence.
UNASSIGNED: This is a retrospective multicenter cross-sectional study of pediatric patients diagnosed with CNO. A total of 87 patients with a diagnosis of CNO followed for at least 6 months in 8 pediatric rheumatology centers across the country between January 2010 and December 2021 were included in this study.
UNASSIGNED: The study included 87 patients (38 girls, 49 boys; median age: 12.5 years). The median follow-up time was 20 months (IQR: 8.5-40). The median time of diagnostic delay was 9.9 months (IQR: 3-24). Arthralgia and bone pain were the most common presenting symptoms. Multifocal involvement was detected in 86.2% of the cases and a recurrent course was reported in one-third of those included in the study. The most commonly involved bones were the femur and tibia. Vertebrae and clavicles were affected in 19.5% and 20.6% of cases, respectively. The erythrocyte sedimentation rate (ESR) values of 60.9% of the patients were above 20 mm/h and the C-reactive protein values of 44.8% were above 5 mg/L. The remission rate was 13.3% in patients using nonsteroidal antiinflammatory drugs and 75.0% in those using biological drugs. Vertebral and mandibular involvement and high ESR values at the time of diagnosis were associated with recurrence.
UNASSIGNED: In this multicenter study, CNO with vertebral and mandibular involvement and high ESR at diagnosis were associated with recurrence.
摘要：
慢性非细菌性骨髓炎（CNO）是一种病因不明的罕见疾病，最常见于儿童期或青春期。这项研究的目的是收集有关临床特征的数据，结果，和疾病的管理，并确定影响复发的因素。
■这是一项针对诊断为CNO的儿科患者的回顾性多中心横断面研究。本研究纳入了2010年1月至2021年12月间在全国8个儿科风湿病中心随访至少6个月的87例诊断为CNO的患者。
■该研究包括87名患者（38名女孩，49名男孩；平均年龄：12.5岁）。中位随访时间为20个月(IQR:8.5-40)。诊断延迟的中位时间为9.9个月(IQR:3-24)。关节痛和骨痛是最常见的症状。在86.2％的病例中检测到多灶性受累，并且在研究中的三分之一报告了复发过程。最常见的骨骼是股骨和胫骨。分别有19.5%和20.6%的病例影响脊椎和锁骨,分别。60.9%的患者血沉(ESR)值大于20mm/h,44.8%的患者C反应蛋白值大于5mg/L。使用非甾体抗炎药的患者缓解率为13.3％，使用生物药的患者缓解率为75.0％。脊椎和下颌骨受累以及诊断时的高ESR值与复发有关。
■在这项多中心研究中，CNO伴有椎体和下颌骨受累以及诊断时的高ESR与复发有关。
■这是一项针对诊断为CNO的儿科患者的回顾性多中心横断面研究。本研究纳入了2010年1月至2021年12月间在全国8个儿科风湿病中心随访至少6个月的87例诊断为CNO的患者。
■该研究包括87名患者（38名女孩，49名男孩；平均年龄：12.5岁）。中位随访时间为20个月(IQR:8.5-40)。诊断延迟的中位时间为9.9个月(IQR:3-24)。关节痛和骨痛是最常见的症状。在86.2％的病例中检测到多灶性受累，并且在研究中的三分之一报告了复发过程。最常见的骨骼是股骨和胫骨。分别有19.5%和20.6%的病例影响脊椎和锁骨,分别。60.9%的患者血沉(ESR)值大于20mm/h,44.8%的患者C反应蛋白值大于5mg/L。使用非甾体抗炎药的患者缓解率为13.3％，使用生物药的患者缓解率为75.0％。脊椎和下颌骨受累以及诊断时的高ESR值与复发有关。
■在这项多中心研究中，CNO伴有椎体和下颌骨受累以及诊断时的高ESR与复发有关。
