UNASSIGNED: A total of 5438 patients were analyzed in this study, including 240 patients underwent PF-TESA ICSI (ICSI using PF triggered frozen-thawed testicular spermatozoa), 101 patients underwent non-PF TESA ICSI (ICSI using frozen-thawed testicular spermatozoa) and 5097 patients underwent conventional ICSI using fresh ejaculation. Propensity score matching was executed to control the various characteristics of patients.
UNASSIGNED: No significant differences in pregnancy outcomes were observed among the three groups (PF-TESA ICSI, non-PF TESA ICSI and conventional ICSI), including biochemical pregnancy, clinical pregnancy, implantation, miscarriage, ectopic pregnancy, multiple pregnancy, and live birth, following propensity score matching. Additionally, neonatal outcomes were found to be similar among the three groups, with no statistical differences observed in the birth defect, birth weight, gestational age, preterm birth, and early-neonatal death.
UNASSIGNED: PF-ICSI may be an alternative treatment in patients using frozen-thawed testicular spermatozoa, resulting in comparable pregnancy and neonatal outcomes.
■本研究共分析了5438例患者,包括240例接受PF-TESAICSI(ICSI使用PF触发的冻融睾丸精子),101例患者接受了非PFTESAICSI(使用冻融睾丸精子的ICSI),5097例患者接受了使用新鲜射精的常规ICSI。进行倾向评分匹配以控制患者的各种特征。
■三组间妊娠结局无显著差异(PF-TESAICSI,非PFTESAICSI和常规ICSI),包括生化妊娠,临床妊娠,植入,流产,异位妊娠,多胎妊娠,和活产,遵循倾向得分匹配。此外,三组的新生儿结局相似,在出生缺陷方面没有观察到统计学差异,出生体重,胎龄,早产,和新生儿早期死亡。
■PF-ICSI可能是使用冻融睾丸精子的患者的替代治疗方法,导致具有可比性的妊娠和新生儿结局。