PDF(Pubmed)
Abstract：
Spinal cord injury (SCI) can cause loss of sensory and motor function below the level of injury, posing a serious threat to human health and quality of life. One significant characteristic feature of pathological changes following injury in the nervous system is demyelination, which partially contributes to the long-term deficits in neural function after injury. The remyelination in the central nervous system (CNS) is mainly mediated by oligodendrocyte progenitor cells (OPCs). Numerous complex intracellular signaling and transcriptional factors regulate the differentiation process from OPCs to mature oligodendrocytes (OLs) and myelination. Studies have shown the importance of microRNA (miRNA) in regulating OPC functions. In this review, we focus on the demyelination and remyelination after SCI, and summarize the progress of miRNAs on OPC functions and remyelination, which might provide a potential therapeutic target for SCI treatments.
摘要：
脊髓损伤（SCI）可导致损伤水平以下的感觉和运动功能丧失，严重威胁人类的健康和生活质量。神经系统损伤后病理变化的一个重要特征是脱髓鞘，部分导致损伤后神经功能的长期缺陷。中枢神经系统（CNS）的髓鞘再生主要由少突胶质祖细胞（OPCs）介导。许多复杂的细胞内信号和转录因子调节从OPCs到成熟少突胶质细胞(OLs)和髓鞘形成的分化过程。研究表明microRNA(miRNA)在调节OPC功能中的重要性。在这次审查中,本文对SCI后脱髓鞘和髓鞘再生进行了综述,这可能为SCI治疗提供潜在的治疗靶点。
