UNASSIGNED: Thirty periodontitis patients (15 with DM and 15 with SH) were included in the study, which had a split-mouth design, by applying LBT in the mouth of the same systemic condition. Thus, 4 study groups were formed, as 1) NSPT - DM: NSPT alone in DM, 2) NSPT + LBT - DM: NSPT + LBT application in DM, 3) NSPT - SH: NSPT alone in SH, and 4) NSPT + LBT - SH: NSPT + LBT application in SH. NSPT was performed on days 15, 30, 37, 44, 51, 58, and 65. LBT was performed 6 times on days 30, 37, 44, 51, 58, and 65 with an Nd:YAG laser. The plaque index (PI), gingival index (GI), bleeding on probing (BOP), probing pocket depth (PPD), and clinical attachment level (CAL) were assessed as the clinical parameters and recorded at baseline and days 30, 37, and 72. Gingival crevicular fluid levels of interleukin 1 beta (IL-1β) and IL-10 were evaluated by ELISA as the biochemical parameters at baseline and on days 30, 37, and 72.
UNASSIGNED: Clinical parameters had improved in all of the groups on day 72 (p < 0.01). PPD and CAL improved more in the DM group with NSPT and LBT group than in the DM group with NSPT without LBT on day 37 (p < 0.05). IL-1β decreased and IL-10 increased in all of the groups on day 72 (p < 0.01). This change was more evident in the DM group with NSPT and LBT than in the DM group with NSPT without LBT on day 7 (p < 0.05).
UNASSIGNED: These results revealed the short-term impacts of LBT on periodontal healing, which return to ineffectiveness with repeated irradiation. Therefore, it may be speculated that LBT via the protocol herein may have a short-term antiinflammatory contribution to NSPT, only in impaired healing conditions such as DM.
■30例牙周炎患者(15例DM和15例SH)被纳入研究,有裂口设计,通过在相同全身状况的口腔中应用LBT。因此,成立了4个研究组,作为1)NSPT-DM:DM中单独使用NSPT,2)NSPT+LBT-DM:NSPT+LBT在DM中的应用,3)NSPT-SH:仅在SH中使用NSPT,4)NSPT+LBT-SH:NSPT+LBT在SH的应用。在第15、30、37、44、51、58和65天进行NSPT。在第30、37、44、51、58和65天用Nd:YAG激光进行6次LBT。菌斑指数(PI),牙龈指数(GI),探查出血(BOP),探测袋深度(PPD),和临床依恋水平(CAL)作为临床参数进行评估,并在基线和第30,37和72天进行记录.通过ELISA评估白细胞介素1β(IL-1β)和IL-10的龈沟液水平,作为基线和第30、37和72天的生化参数。
■在第72天,所有组的临床参数都有改善(p<0.01)。在第37天,有NSPT和LBT的DM组的PPD和CAL改善程度高于无LBT的NSPT的DM组(p<0.05)。在第72天,所有组的IL-1β降低,IL-10升高(p<0.01)。在第7天有NSPT和LBT的DM组中,这种变化比没有LBT的NSPT的DM组中更明显(p<0.05)。
■这些结果揭示了LBT对牙周愈合的短期影响,反复照射会导致无效。因此,可以推测,通过本文的方案进行的LBT可能对NSPT具有短期抗炎作用,仅在受损的愈合条件,如DM。