PDF(Pubmed)
Abstract：
UNASSIGNED: Scaling and root planing remain inadequate in periodontitis treatment caused by dysbiotic microbial dental plaque. The aim of this clinical trial is to evaluate the effects of probiotics and kefir consumption in initial periodontal therapy (IPT) on oral microbiota composition and treatment outcomes in patients with periodontitis.
UNASSIGNED: The study was carried out in the Gazi University Department of Periodontology, including a sample size of 36 individuals and utilizing a randomized controlled design. Thirty-six patients with periodontitis were randomly allocated to three groups: one receiving probiotic treatment, another receiving kefir, and a third serving as the control group. Obtaining subgingival microbial samples, we recorded plaque, gingival index, bleeding on probing, periodontal pocket depth, and clinical attachment level (periodontal clinical indices) and then performed IPT. For 14 days, patients took either probiotics, kefir, or no supplements. Data for the first and third months were collected using periodontal clinical indices. DNA sequencing was performed to detect Tannerella forsythia, Porphyromonas gingivalis, and Treponema denticola in subgingival plaque samples collected at baseline and three months.
UNASSIGNED: Significant differences were observed regarding periodontal clinical indices among groups in the intragroup comparisons. Moreover, levels of Tannerella forsythia were significantly decreased in all groups.
UNASSIGNED: Kefir can be administered in addition to IPT, providing results similar to those observed with probiotics.
UNASSIGNED: The study was carried out in the Gazi University Department of Periodontology, including a sample size of 36 individuals and utilizing a randomized controlled design. Thirty-six patients with periodontitis were randomly allocated to three groups: one receiving probiotic treatment, another receiving kefir, and a third serving as the control group. Obtaining subgingival microbial samples, we recorded plaque, gingival index, bleeding on probing, periodontal pocket depth, and clinical attachment level (periodontal clinical indices) and then performed IPT. For 14 days, patients took either probiotics, kefir, or no supplements. Data for the first and third months were collected using periodontal clinical indices. DNA sequencing was performed to detect Tannerella forsythia, Porphyromonas gingivalis, and Treponema denticola in subgingival plaque samples collected at baseline and three months.
UNASSIGNED: Significant differences were observed regarding periodontal clinical indices among groups in the intragroup comparisons. Moreover, levels of Tannerella forsythia were significantly decreased in all groups.
UNASSIGNED: Kefir can be administered in addition to IPT, providing results similar to those observed with probiotics.
摘要：
■在由生态失调性微生物菌斑引起的牙周炎治疗中，缩放和根部平整仍然不足。这项临床试验的目的是评估初始牙周治疗（IPT）中益生菌和开菲尔消费对牙周炎患者口腔微生物群组成和治疗结果的影响。
■这项研究是在加齐大学牙周学系进行的，包括36个人的样本量，并采用随机对照设计。36例牙周炎患者随机分为三组：一组接受益生菌治疗，另一个接收开菲尔，和第三个作为对照组。获取龈下微生物样本，我们记录了斑块,牙龈指数,探查时出血,牙周袋深度，和临床附着水平（牙周临床指标），然后进行IPT。14天,患者服用了益生菌，kefir,或者没有补充。使用牙周临床指标收集第一和第三个月的数据。进行DNA测序以检测连翘坦菌，牙龈卟啉单胞菌,在基线和3个月时收集的龈下菌斑样本中的密螺旋体和密螺旋体。
■在组间比较中观察到牙周临床指标的显着差异。此外，各组连翘坦菌水平均显著降低。
■除IPT外，还可以使用开菲尔，提供与益生菌观察到的结果相似的结果。
■这项研究是在加齐大学牙周学系进行的，包括36个人的样本量，并采用随机对照设计。36例牙周炎患者随机分为三组：一组接受益生菌治疗，另一个接收开菲尔，和第三个作为对照组。获取龈下微生物样本，我们记录了斑块,牙龈指数,探查时出血,牙周袋深度，和临床附着水平（牙周临床指标），然后进行IPT。14天,患者服用了益生菌，kefir,或者没有补充。使用牙周临床指标收集第一和第三个月的数据。进行DNA测序以检测连翘坦菌，牙龈卟啉单胞菌,在基线和3个月时收集的龈下菌斑样本中的密螺旋体和密螺旋体。
■在组间比较中观察到牙周临床指标的显着差异。此外，各组连翘坦菌水平均显著降低。
■除IPT外，还可以使用开菲尔，提供与益生菌观察到的结果相似的结果。
