PDF(Pubmed)
Abstract：
UNASSIGNED: Anemia in the first week after birth, which could affect growth, development, and organ function, should be an important warning sign to clinicians. The aim of this study was to assess the related risk factors of early neonatal anemia and to analyze the effect of anemia on the expression levels of myocardial markers in newborns.
UNASSIGNED: Clinical data from 122 confirmed cases of anemic newborns and 108 nonanemic newborns were collected to analyze the independent risk factors for early anemia using logistic regression analyses. Blood samples were collected from both groups for the detection of myocardial markers, including the protein marker cardiac troponin T (cTnT), as well as enzyme markers creatine kinase isoenzyme MB (CK-MB) and lactate dehydrogenase (LDH).
UNASSIGNED: Multivariate logistic regression analysis revealed that preterm birth (OR: 3.589 [1.119-11.506], p < 0.05), multiple pregnancy (OR: 4.117 [1.021-16.611], p < 0.05), and abnormal placenta (OR: 4.712 [1.077-20.625], p < 0.05) were independent risk factors for early neonatal anemia. The levels of myocardial markers, including cTnT (303.1 ± 244.7 vs. 44.2 ± 55.41 ng/L), CK-MB (6.803 ± 8.971 vs. 2.5326 ± 2.927 μkat/L), and LDH (32.42 ± 35.26 vs. 19.73 ± 17.13 μkat/L), were significantly higher in the anemic group than in the nonanemic group.
UNASSIGNED: Multiple pregnancy, preterm birth, and abnormal placenta were identified as risk factors for early neonatal anemia. The occurrence of early neonatal anemia was associated with increased levels of myocardial markers.
UNASSIGNED: Clinical data from 122 confirmed cases of anemic newborns and 108 nonanemic newborns were collected to analyze the independent risk factors for early anemia using logistic regression analyses. Blood samples were collected from both groups for the detection of myocardial markers, including the protein marker cardiac troponin T (cTnT), as well as enzyme markers creatine kinase isoenzyme MB (CK-MB) and lactate dehydrogenase (LDH).
UNASSIGNED: Multivariate logistic regression analysis revealed that preterm birth (OR: 3.589 [1.119-11.506], p < 0.05), multiple pregnancy (OR: 4.117 [1.021-16.611], p < 0.05), and abnormal placenta (OR: 4.712 [1.077-20.625], p < 0.05) were independent risk factors for early neonatal anemia. The levels of myocardial markers, including cTnT (303.1 ± 244.7 vs. 44.2 ± 55.41 ng/L), CK-MB (6.803 ± 8.971 vs. 2.5326 ± 2.927 μkat/L), and LDH (32.42 ± 35.26 vs. 19.73 ± 17.13 μkat/L), were significantly higher in the anemic group than in the nonanemic group.
UNASSIGNED: Multiple pregnancy, preterm birth, and abnormal placenta were identified as risk factors for early neonatal anemia. The occurrence of early neonatal anemia was associated with increased levels of myocardial markers.
摘要：
■出生后第一周贫血，这可能会影响增长，发展,和器官功能，应该是临床医生的重要警示标志。本研究旨在评估早期新生儿贫血的相关危险因素,分析贫血对新生儿心肌标志物表达水平的影响。
■收集了122例确诊的贫血新生儿和108例非贫血新生儿的临床数据，使用logistic回归分析分析早期贫血的独立危险因素。两组均采集血样检测心肌标志物,包括蛋白质标志物心肌肌钙蛋白T（cTnT），以及酶标记肌酸激酶同工酶MB（CK-MB）和乳酸脱氢酶（LDH）。
■多变量逻辑回归分析显示早产（OR：3.589[1.119-11.506]，p<0.05)，多胎妊娠（OR：4.117[1.021-16.611]，p<0.05)，和异常胎盘（OR：4.712[1.077-20.625]，p<0.05)是早期新生儿贫血的独立危险因素。心肌标志物的水平，包括cTnT(303.1±244.7vs.44.2±55.41纳克/升)，CK-MB(6.803±8.971vs.2.5326±2.927μkat/L),和LDH（32.42±35.26vs.19.73±17.13μkat/L),贫血组明显高于非贫血组。
■多胎妊娠,早产,胎盘异常被确定为早期新生儿贫血的危险因素。早期新生儿贫血的发生与心肌标志物水平升高有关。
■收集了122例确诊的贫血新生儿和108例非贫血新生儿的临床数据，使用logistic回归分析分析早期贫血的独立危险因素。两组均采集血样检测心肌标志物,包括蛋白质标志物心肌肌钙蛋白T（cTnT），以及酶标记肌酸激酶同工酶MB（CK-MB）和乳酸脱氢酶（LDH）。
■多变量逻辑回归分析显示早产（OR：3.589[1.119-11.506]，p<0.05)，多胎妊娠（OR：4.117[1.021-16.611]，p<0.05)，和异常胎盘（OR：4.712[1.077-20.625]，p<0.05)是早期新生儿贫血的独立危险因素。心肌标志物的水平，包括cTnT(303.1±244.7vs.44.2±55.41纳克/升)，CK-MB(6.803±8.971vs.2.5326±2.927μkat/L),和LDH（32.42±35.26vs.19.73±17.13μkat/L),贫血组明显高于非贫血组。
■多胎妊娠,早产,胎盘异常被确定为早期新生儿贫血的危险因素。早期新生儿贫血的发生与心肌标志物水平升高有关。
