PDF(Pubmed)
Abstract：
Contrast enhancement resolution induced by corticosteroids is a phenomenon primarily associated with primary central nervous system lymphoma, while malignant brain gliomas usually maintain a consistent radiological appearance during systemic steroid treatment. Although rare, a few primary and metastatic intracranial lesions have shown similar radiographic changes following corticosteroid therapy. In the case of glioblastomas, corticosteroid therapy is commonly used to alleviate pressure effects from peritumoral edema, but its impact on contrast enhancement is not well-established. A few reported cases in the literature describe reduced contrast enhancement in glioblastomas after corticosteroid treatment. We present a case of corticosteroid-induced regression on imaging of glioblastoma evaluated at our institutionwith the intention to explore the pathogenesis of this response and discuss the therapeutic and prognostic implications of this discovery.
摘要：
皮质类固醇诱导的对比增强分辨率是一种主要与原发性中枢神经系统淋巴瘤有关的现象，而恶性脑胶质瘤通常在全身类固醇治疗期间保持一致的放射学外观。虽然罕见，一些原发性和转移性颅内病变在糖皮质激素治疗后表现出相似的影像学改变.在胶质母细胞瘤的情况下，皮质类固醇治疗通常用于减轻肿瘤周围水肿的压力影响，但其对对比度增强的影响尚不明确。文献中的一些报道病例描述了皮质类固醇治疗后胶质母细胞瘤的对比度增强降低。我们介绍了在我们的机构评估的胶质母细胞瘤影像学上皮质类固醇诱导的消退情况，旨在探索这种反应的发病机理，并讨论这一发现的治疗和预后意义。
