PDF(Pubmed)
Abstract：
Gingival enlargement is a side effect of several different medication, including immunosuppressants, anticonvulsants, and calcium channel blockers. It is an inflammatory response that starts when plaque and calculus build up on the tooth surface. The most prevalent long-term neurological condition affecting people is epilepsy. In affluent nations, the prevalence of epilepsy is ~ 1%, whereas in less developed countries, it may >2%. The preferred medication for the condition, phenytoin, has major side effects include gingival enlargement. In addition to being visually disfiguring, this enlargement frequently affects speech, chewing and eating. Furthermore, those with poor dental hygiene, causes disabilities with motor coordination and muscular limitations leading to mental disability and physical impairments are more prone to periodontal disease. This article enlightened the mechanism of drug induced gingival enlargement clinically, microbiologically, and surgically.
摘要：
牙龈增大是几种不同药物的副作用，包括免疫抑制剂,抗惊厥药,和钙通道阻滞剂.这是一种炎症反应，当牙菌斑和结石在牙齿表面积聚时开始。影响人们的最普遍的长期神经系统疾病是癫痫。在富裕国家,癫痫的患病率约为1％，而在欠发达国家,可能>2%。这种情况的首选药物，苯妥英,主要副作用包括牙龈肿大。除了在视觉上毁容，这种扩大经常影响语音，咀嚼和吃。此外，那些牙齿卫生不好的人，导致残疾的运动协调和肌肉限制导致精神残疾和身体损伤更容易患牙周病。本文从临床上对药物引起牙龈肿大的机制进行了启示，微生物学，和手术。
