PDF(Pubmed)
Abstract：
Peste des petits ruminants virus (PPRV) is a morbillivirus that causes the acute and highly pathogenic infectious disease peste des petits ruminants (PPR) in small ruminants and poses a major threat to the goat and sheep industries. Currently, there is no effective treatment for PPRV infection. Here, we propose Carboplatin, a platinum-based regimen designed to treat a range of malignancies, as a potential antiviral agent. We showed that Carboplatin exhibits significant antiviral activity against PPRV in a cell culture model. The mechanism of action of Carboplatin against PPRV is mainly attributed to its ability to block STING mediated autophagy. Together, our study supports the discovery of Carboplatin as an antiviral against PPRV and potentially other closely related viruses, sheds light on its mode of action, and establishes STING as a valid and attractive target to counteract viral infection.
摘要：
小反刍动物(PPRV)是一种引起小反刍动物急性和高致病性小反刍动物(PPR)传染病的麻类病毒，对山羊和绵羊产业构成重大威胁。目前,对于PPRV感染尚无有效的治疗方法。这里,我们建议卡铂，一种基于铂的治疗方案，旨在治疗一系列恶性肿瘤，作为潜在的抗病毒剂。我们表明卡铂在细胞培养模型中表现出针对PPRV的显着抗病毒活性。卡铂抗PPRV的作用机制主要归因于其阻断STING介导的自噬的能力。一起,我们的研究支持卡铂作为抗PPRV和潜在的其他密切相关的病毒的抗病毒发现，揭示了它的作用方式，并将STING确立为有效且有吸引力的目标，以抵抗病毒感染。
