PDF(Pubmed)
Abstract：
Cellular senescence, a condition where cells undergo arrest and can assume an inflammatory phenotype, has been associated with initiation and perpetuation of inflammation driving multiple disease processes in rodent models and humans. Senescent cells secrete inflammatory cytokines, proteins, and matrix metalloproteinases, termed the senescence associated secretory phenotype (SASP), which accelerates the aging processes. In preclinical models, drug interventions termed \"senotherapeutics\" selectively clear senescent cells and represent a promising strategy to prevent or treat multiple age-related conditions in humans and veterinary species. In this review, we summarize the current available literature describing in vitro evidence for senotheraputic activity, preclinical models of disease, ongoing human clinical trials, and potential clinical applications in veterinary medicine. These promising data to date provide further justification for future studies identifying the most active senotherapeutic combinations, dosages, and routes of administration for use in veterinary medicine.
摘要：
细胞衰老,细胞经历停滞并可以呈现炎症表型的情况，在啮齿动物模型和人类中，与炎症驱动多种疾病过程的启动和延续有关。衰老细胞分泌炎性细胞因子，蛋白质，和基质金属蛋白酶，称为衰老相关分泌表型(SASP)，加速老化过程。在临床前模型中，称为“senotherapeutics”的药物干预措施选择性清除衰老细胞，代表了一种有希望的策略，可以预防或治疗人类和兽医物种中多种与年龄相关的疾病。在这次审查中,我们总结了目前可用的文献，描述了在体外的证据，疾病的临床前模型，正在进行的人体临床试验，以及在兽医学中的潜在临床应用。迄今为止，这些有希望的数据为未来研究确定最活跃的药物治疗组合提供了进一步的理由。剂量,以及用于兽药的给药途径。
