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Abstract：
UNASSIGNED: To evaluate the clinical efficacy of different androgen deprivation therapies for prostate cancer (PCa) based on dynamic-contrast enhanced magnetic resonance imaging (DCE-MRI).
UNASSIGNED: 104 patients with PCa were studied, all of whom were treated with androgen deprivation therapy. The patients were divided into a continuous group (continuous androgen deprivation therapy) and an intermittent group (intermittent androgen deprivation therapy) by random number table method, 52 cases/group. The therapeutic effect and DCE-MRI indices were compared and the relationship between DCE-MRI indices and clinical efficacy and the evaluation value of therapeutic efficacy were analyzed.
UNASSIGNED: The objective response rate (ORR) of the intermittent group was higher than that of the continuous group (p < 0.05), and there was no significant difference in disease control rate (DCR) between the two groups (p > 0.05). After treatment, volume transfer coefficient (Ktrans), reverse transfer constant (Kep), volume fraction (Ve), blood volume (BV), and blood flow (BF) in both groups were lowered, and those in the intermittent group were lower than the continuous group (p < 0.05). Ktrans, Kep, Ve, BF, and BV in the ORR group were lower than those in the non-ORR group (p < 0.05). Ktrans, Kep, Ve, BF, and BV were correlated with the therapeutic effect of PCa (p < 0.05). The AUC value of the combined detection of DCE-MRI indices in evaluating the therapeutic effect of PCa was greater than that of each index alone (p < 0.05).
UNASSIGNED: Compared with continuous androgen deprivation therapy, intermittent androgen deprivation therapy has better clinical efficacy in the treatment of PCa, and DCE-MRI indices are related to the treatment efficacy of PCa and have an evaluation value.
UNASSIGNED: 104 patients with PCa were studied, all of whom were treated with androgen deprivation therapy. The patients were divided into a continuous group (continuous androgen deprivation therapy) and an intermittent group (intermittent androgen deprivation therapy) by random number table method, 52 cases/group. The therapeutic effect and DCE-MRI indices were compared and the relationship between DCE-MRI indices and clinical efficacy and the evaluation value of therapeutic efficacy were analyzed.
UNASSIGNED: The objective response rate (ORR) of the intermittent group was higher than that of the continuous group (p < 0.05), and there was no significant difference in disease control rate (DCR) between the two groups (p > 0.05). After treatment, volume transfer coefficient (Ktrans), reverse transfer constant (Kep), volume fraction (Ve), blood volume (BV), and blood flow (BF) in both groups were lowered, and those in the intermittent group were lower than the continuous group (p < 0.05). Ktrans, Kep, Ve, BF, and BV in the ORR group were lower than those in the non-ORR group (p < 0.05). Ktrans, Kep, Ve, BF, and BV were correlated with the therapeutic effect of PCa (p < 0.05). The AUC value of the combined detection of DCE-MRI indices in evaluating the therapeutic effect of PCa was greater than that of each index alone (p < 0.05).
UNASSIGNED: Compared with continuous androgen deprivation therapy, intermittent androgen deprivation therapy has better clinical efficacy in the treatment of PCa, and DCE-MRI indices are related to the treatment efficacy of PCa and have an evaluation value.
摘要：
■基于动态对比增强磁共振成像（DCE-MRI）评估不同雄激素剥夺疗法对前列腺癌（PCa）的临床疗效。
■研究了104例PCa患者，所有患者均接受雄激素剥夺治疗.采用随机数字表法将患者分为连续组(连续性雄激素剥夺治疗)和间歇组(间歇性雄激素剥夺治疗),52例/组。比较两组患者的治疗效果和DCE-MRI指标,分析DCE-MRI指标与临床疗效的关系及疗效的评估价值。
■间歇组的客观反应率（ORR）高于连续组（p<0.05），两组疾病控制率(DCR)比较差异无统计学意义(p>0.05)。治疗后,体积传递系数(Ktrans)，反向传输常数（Kep），体积分数（Ve），血容量（BV），两组的血流量（BF）均降低，间歇组低于连续组(p<0.05)。Ktrans,Kep,Ve,BF,ORR组BV低于非ORR组(p<0.05)。Ktrans,Kep,Ve,BF,BV与PCa疗效相关(p<0.05)。联合检测DCE-MRI指标评价PCa疗效的AUC值均大于单独检测各指标的AUC值(p<0.05)。
■与持续雄激素剥夺治疗相比，间歇性雄激素剥夺治疗PCa有较好的临床疗效,DCE-MRI指标与PCa的治疗效果相关,具有评价价值。
■研究了104例PCa患者，所有患者均接受雄激素剥夺治疗.采用随机数字表法将患者分为连续组(连续性雄激素剥夺治疗)和间歇组(间歇性雄激素剥夺治疗),52例/组。比较两组患者的治疗效果和DCE-MRI指标,分析DCE-MRI指标与临床疗效的关系及疗效的评估价值。
■间歇组的客观反应率（ORR）高于连续组（p<0.05），两组疾病控制率(DCR)比较差异无统计学意义(p>0.05)。治疗后,体积传递系数(Ktrans)，反向传输常数（Kep），体积分数（Ve），血容量（BV），两组的血流量（BF）均降低，间歇组低于连续组(p<0.05)。Ktrans,Kep,Ve,BF,ORR组BV低于非ORR组(p<0.05)。Ktrans,Kep,Ve,BF,BV与PCa疗效相关(p<0.05)。联合检测DCE-MRI指标评价PCa疗效的AUC值均大于单独检测各指标的AUC值(p<0.05)。
■与持续雄激素剥夺治疗相比，间歇性雄激素剥夺治疗PCa有较好的临床疗效,DCE-MRI指标与PCa的治疗效果相关,具有评价价值。
