Abstract：
Nasopharyngeal carcinoma (NPC) is an aggressive head and neck tumor that is influenced by a variety of molecular factors during its pathogenesis. Among these, the phosphatase and tensin homolog (PTEN) plays a crucial role in regulatory networks. This article systematically reviews the multifaceted functions of PTEN in NPC, including its roles in inhibiting cell proliferation, regulating migration and invasion, promoting autophagy and apoptosis, and influencing resistance to radiotherapy. Molecular factors such as long non-coding RNA, microRNA (miRNA), and circular RNA can modulate PTEN through various pathways, thereby impacting the biological behavior of NPC. In addition, PTEN is involved in regulating the tumor microenvironment of NPC, and its interaction with the Epstein-Barr virus has also recently become a focus of research. A comprehensive understanding of the PTEN regulatory network provides a foundation for future personalized and targeted therapeutic strategies. This study expands our understanding of the pathogenesis of NPC and suggests new directions in the field of tumor biology and NPC treatment.
摘要：
鼻咽癌(NPC)是一种侵袭性头颈部肿瘤,其发病过程受多种分子因素的影响。其中,磷酸酶和张力蛋白同源物（PTEN）在调节网络中起着至关重要的作用。本文系统地回顾了PTEN在鼻咽癌中的多方面功能,包括其抑制细胞增殖的作用，调节迁移和入侵，促进自噬和凋亡，并影响对放疗的抵抗力。分子因素，如长非编码RNA，microRNA(miRNA),环状RNA可以通过各种途径调节PTEN，从而影响NPC的生物学行为。此外,PTEN参与调节鼻咽癌的肿瘤微环境,其与爱泼斯坦-巴尔病毒的相互作用最近也成为研究的焦点。对PTEN监管网络的全面理解为未来个性化和有针对性的治疗策略奠定了基础。这项研究扩展了我们对NPC发病机制的理解，并为肿瘤生物学和NPC治疗领域提供了新的方向。
