Abstract：
The Warburg effect, also called aerobic glycolysis, refers to tumor cells that metabolize glucose through glycolysis even in the presence of oxygen. This rapid breakdown of glucose fuels the fast development, growth, and migration of tumor cells. Lactate, the final product of aerobic glycolysis, contributes to an acidic environment within the tumor, promoting the formation of an immunosuppressive microenvironment and accelerating tumor progression by impeding anti-tumor immunity. Numerous studies have confirmed the critical role of aerobic glycolysis in the occurrence and development of hepatocellular carcinoma by influencing tumor cells proliferation, invasion, metastasis, apoptosis, immune escape, angiogenesis, and more. Clinical trials have shown that inhibitors of rate-limiting enzymes in the glycolysis pathway can enhance the effectiveness of sorafenib, a targeted drug for hepatocellular carcinoma, by reducing drug resistance. Additionally, active components of traditional Chinese medicine and specific compound prescriptions are gaining attention for their potential to target and regulate aerobic glycolysis in hepatocellular carcinoma. Therefore, inhibiting the aerobic glycolysis pathway holds promise as a therapeutic strategy for treating liver tumors. This manuscript aims to review the role, research directions, and clinical studies of aerobic glycolysis in hepatocellular carcinoma.
摘要：
Warburg效应,也称为有氧糖酵解，指即使在氧存在下也通过糖酵解代谢葡萄糖的肿瘤细胞。葡萄糖的快速分解推动了快速发展，增长,和肿瘤细胞的迁移。乳酸,有氧糖酵解的最终产物，有助于肿瘤内的酸性环境，通过阻碍抗肿瘤免疫促进免疫抑制微环境的形成和加速肿瘤进展。大量研究证实了有氧糖酵解通过影响肿瘤细胞的增殖在肝癌的发生发展中的重要作用,入侵,转移,凋亡，免疫逃逸，血管生成,还有更多.临床试验表明，糖酵解途径中的限速酶抑制剂可以增强索拉非尼的有效性，一种针对肝细胞癌的靶向药物，通过减少耐药性。此外,中药的有效成分和特定的复方处方因其在肝细胞癌中靶向和调节有氧糖酵解的潜力而受到关注。因此,抑制有氧糖酵解途径有望作为治疗肝肿瘤的治疗策略。这份手稿旨在回顾角色，研究方向,和肝细胞癌有氧糖酵解的临床研究。
