Abstract：
Piperlongumine(PL), a natural alkaloid extracted from Piperis Longi Fructus, has attracted much attention in recent years because of its strong anti-tumor activity, little toxicity to normal cells, and excellent sensitizing effect combined with chemotherapy and radiotherapy, which endow PL with unique advantages as an anti-tumor drug. However, similar to other alkaloids, PL has low water solubility and poor bioavailability. To improve the application of PL in the clinical treatment of tumors, researchers have constructed various nano-drug delivery systems to increase the efficiency of PL delivery. This paper reviewed the physicochemical properties, anti-tumor mechanism, combined therapies, and nano-drug delivery systems of PL in recent years. The review aimed to provide a reference for further research on the anti-tumor effect and nano-drug delivery system of PL. Moreover, this review is expected to provide a reference for the development and application of PL in the anti-tumor therapies.
摘要：
胡椒长胺（PL），从龙子中提取的一种天然生物碱，近年来因其具有很强的抗肿瘤活性而备受关注,对正常细胞毒性很小,并结合化疗和放疗，具有良好的增敏作用，使PL作为抗肿瘤药物具有独特的优势。然而,与其他生物碱相似，PL具有低的水溶性和差的生物利用度。提高PL在肿瘤临床治疗中的应用,研究人员已经构建了各种纳米药物递送系统来提高PL递送效率。本文综述了研究对象的理化性质,抗肿瘤机制，联合疗法,以及近年来PL的纳米给药系统。旨在为进一步研究PL的抗肿瘤作用和纳米载药系统提供参考。此外，本综述有望为PL在抗肿瘤治疗中的发展和应用提供参考。
