PDF(Pubmed)
Abstract：
The spatiotemporal heterogeneity of neurons, circuits and regulators is being uncovered at a single-cell level, from single-cell gene expression to functional regulations. The classifications, architectonics and functional communications amongst neural cells and circuits within the brain can be clearly delineated using single-cell multiomics and transomics. This Editorial highlights the spatiotemporal heterogeneity of neurons and circuits as well as regulators, initiates the translation of neuronal diversity and spatial organisation at single-cell levels into clinical considerations, and enables the discovery and development of new therapies for neurological diseases. It is predicted that single-cell and spatial multiomics will be integrated with metabolomic profiles and corresponding gene epigenetic modifications. The interactions amongst DNAs, RNAs and proteins in a cell provide details of intracellular functional regulations and new opportunities for the translation of temporospatial diversity of neural cell subtypes/states into clinical practice. The application of single-cell multiomics with four-dimensional genome to the human pathological brain will lead us to a new milestone of the diagnosis and treatment.
摘要：
神经元的时空异质性，电路和调节器在单细胞层面被揭露，从单细胞基因表达到功能调控。分类，脑内神经细胞和回路之间的结构学和功能通信可以使用单细胞多组学和转组学清楚地描绘。这篇社论强调了神经元和电路以及调节器的时空异质性，开始将单细胞水平的神经元多样性和空间组织转化为临床考虑因素，并能够发现和开发神经疾病的新疗法。预计单细胞和空间多组学将与代谢组学谱和相应的基因表观遗传修饰整合在一起。DNA之间的相互作用，细胞中的RNA和蛋白质提供了细胞内功能调节的细节以及将神经细胞亚型/状态的时空多样性转化为临床实践的新机会。具有四维基因组的单细胞多组学在人类病理大脑中的应用将为我们的诊断和治疗带来新的里程碑。
