PDF(Pubmed)
Abstract：
BACKGROUND: Left ventricular global longitudinal strain (GLS) holds greater diagnostic and prognostic value than left ventricular ejection fraction (LVEF) in the heart failure (HF) patients. The triglyceride-glucose (TyG) index serves as a reliable surrogate for insulin resistance (IR) and is strongly associated with several adverse cardiovascular events. However, there remains a research gap concerning the correlation between the TyG index and GLS among patients with chronic heart failure (CHF).
METHODS: 427 CHF patients were included in the final analysis. Patient demographic information, along with laboratory tests such as blood glucose, lipids profiles, and echocardiographic data were collected. The TyG index was calculated as Ln [fasting triglyceride (TG) (mg/dL) × fasting plasma glucose (FPG) (mg/dL)/2].
RESULTS: Among CHF patients, GLS was notably lower in the higher TyG index group compared to the lower TyG index group. Following adjustment for confounding factors, GLS demonstrated gradual decrease with increasing TyG index, regardless of the LVEF level and CHF classification.
CONCLUSIONS: Elevated TyG index may be independently associated with more severe clinical left ventricular dysfunction in patients with CHF.
METHODS: 427 CHF patients were included in the final analysis. Patient demographic information, along with laboratory tests such as blood glucose, lipids profiles, and echocardiographic data were collected. The TyG index was calculated as Ln [fasting triglyceride (TG) (mg/dL) × fasting plasma glucose (FPG) (mg/dL)/2].
RESULTS: Among CHF patients, GLS was notably lower in the higher TyG index group compared to the lower TyG index group. Following adjustment for confounding factors, GLS demonstrated gradual decrease with increasing TyG index, regardless of the LVEF level and CHF classification.
CONCLUSIONS: Elevated TyG index may be independently associated with more severe clinical left ventricular dysfunction in patients with CHF.
摘要：
背景：在心力衰竭（HF）患者中，左心室整体纵向应变（GLS）比左心室射血分数（LVEF）具有更大的诊断和预后价值。甘油三酯-葡萄糖（TyG）指数是胰岛素抵抗（IR）的可靠替代指标，并且与一些不良心血管事件密切相关。然而,关于慢性心力衰竭(CHF)患者的TyG指数与GLS之间的相关性仍存在研究空白.
方法：427例CHF患者纳入最终分析。患者人口统计信息，以及血糖等实验室检查，脂质概况，收集超声心动图数据。TyG指数计算为Ln[空腹甘油三酯(TG)(mg/dL)×空腹血糖(FPG)(mg/dL)/2]。
结果：在CHF患者中，与较低的TyG指数组相比，较高的TyG指数组的GLS明显较低。在对混杂因素进行调整后，随着TyG指数的增加，GLS逐渐降低，无论LVEF水平和CHF分类。
结论：在CHF患者中，升高的TyG指数可能与更严重的临床左心功能不全独立相关。
方法：427例CHF患者纳入最终分析。患者人口统计信息，以及血糖等实验室检查，脂质概况，收集超声心动图数据。TyG指数计算为Ln[空腹甘油三酯(TG)(mg/dL)×空腹血糖(FPG)(mg/dL)/2]。
结果：在CHF患者中，与较低的TyG指数组相比，较高的TyG指数组的GLS明显较低。在对混杂因素进行调整后，随着TyG指数的增加，GLS逐渐降低，无论LVEF水平和CHF分类。
结论：在CHF患者中，升高的TyG指数可能与更严重的临床左心功能不全独立相关。
