PDF(Pubmed)
Abstract：
BACKGROUND: With ageing, collagen production slows down, leading to wrinkle appearance and loss of elasticity. Replenishing key structural molecules through oral supplementation is a promising strategy that complements the topical delivery of cosmetic products and creates a holistic skincare regimen. The present study assessed the effectiveness of a food supplement with collagen peptides, vitamins and minerals in improving the quality of the skin and general wellbeing of healthy women.
METHODS: This was an open-label study of 135 women aged between 45 and 65 years. A 3-month treatment phase followed a 4-week washout phase, with visits scheduled at baseline and after each month of treatment. Subjects received three tablets of Richelet Skin Renewal daily. The primary outcome was change from baseline to month 3 in global wrinkles score by expert grader analysis. Secondary outcomes included changes in skin elasticity and other skin attributes, product assessment via self-perception questionnaires and total antioxidant status.
RESULTS: A total of 116 subjects completed the study. The mean global wrinkles score indicated a statistically significant decrease from 5.9 at baseline to 5.0 at month 3 (p < 0.0001), with 83.6% of subjects showing an improvement; significant changes were reported at all intermediate visits. The increase in skin elasticity was also statistically significant (R2 score 0.74 at month 3; p < 0.0001). All subjects (100%) demonstrated significant improvements in skin texture, skin tone evenness, skin radiance and overall skin quality at the month 3 visit.
CONCLUSIONS: The study product achieved statistically significant, noticeable effects on global wrinkles, skin elasticity and a range of skin attributes after 3 months of use in healthy women. These results strengthen the evidence for supplementation of collagen peptides and other micronutrients as an effective component of anti-ageing skincare.
METHODS: This was an open-label study of 135 women aged between 45 and 65 years. A 3-month treatment phase followed a 4-week washout phase, with visits scheduled at baseline and after each month of treatment. Subjects received three tablets of Richelet Skin Renewal daily. The primary outcome was change from baseline to month 3 in global wrinkles score by expert grader analysis. Secondary outcomes included changes in skin elasticity and other skin attributes, product assessment via self-perception questionnaires and total antioxidant status.
RESULTS: A total of 116 subjects completed the study. The mean global wrinkles score indicated a statistically significant decrease from 5.9 at baseline to 5.0 at month 3 (p < 0.0001), with 83.6% of subjects showing an improvement; significant changes were reported at all intermediate visits. The increase in skin elasticity was also statistically significant (R2 score 0.74 at month 3; p < 0.0001). All subjects (100%) demonstrated significant improvements in skin texture, skin tone evenness, skin radiance and overall skin quality at the month 3 visit.
CONCLUSIONS: The study product achieved statistically significant, noticeable effects on global wrinkles, skin elasticity and a range of skin attributes after 3 months of use in healthy women. These results strengthen the evidence for supplementation of collagen peptides and other micronutrients as an effective component of anti-ageing skincare.
摘要：
背景：随着年龄的增长，胶原蛋白生产减慢,导致皱纹外观和失去弹性。通过口服补充补充来补充关键结构分子是一种有前途的策略,其补充化妆品产品的局部递送并创建整体护肤方案。本研究评估了含有胶原蛋白肽的食品补充剂的有效性，维生素和矿物质可改善健康女性的皮肤质量和总体福祉。
方法：这是一项针对135名年龄在45至65岁之间的女性的开放标签研究。3个月的治疗阶段，然后是4周的冲洗阶段，在基线和每个月治疗后安排访视。受试者每天接受三片Richelet皮肤更新。主要结果是从基线到第3个月的整体皱纹评分的变化，通过专家分级分析。次要结果包括皮肤弹性和其他皮肤属性的变化，通过自我感知问卷和总抗氧化剂状态进行产品评估。
结果：共有116名受试者完成了研究。平均整体皱纹评分表明从基线时的5.9到第3个月时的5.0有统计学上的显着下降（p<0.0001），83.6%的受试者表现出改善;在所有中间访视中均报告了显著变化.皮肤弹性的增加也是统计学上显著的(R2评分在第3个月为0.74;p<0.0001)。所有受试者（100％）的皮肤质地显着改善，肤色均匀度，第3个月就诊时的皮肤光泽和整体皮肤质量。
结论：研究产品取得了统计学意义，对全球皱纹的显著影响，在健康女性中使用3个月后，皮肤弹性和一系列皮肤属性。这些结果加强了补充胶原蛋白肽和其他微量营养素作为抗衰老护肤的有效成分的证据。
方法：这是一项针对135名年龄在45至65岁之间的女性的开放标签研究。3个月的治疗阶段，然后是4周的冲洗阶段，在基线和每个月治疗后安排访视。受试者每天接受三片Richelet皮肤更新。主要结果是从基线到第3个月的整体皱纹评分的变化，通过专家分级分析。次要结果包括皮肤弹性和其他皮肤属性的变化，通过自我感知问卷和总抗氧化剂状态进行产品评估。
结果：共有116名受试者完成了研究。平均整体皱纹评分表明从基线时的5.9到第3个月时的5.0有统计学上的显着下降（p<0.0001），83.6%的受试者表现出改善;在所有中间访视中均报告了显著变化.皮肤弹性的增加也是统计学上显著的(R2评分在第3个月为0.74;p<0.0001)。所有受试者（100％）的皮肤质地显着改善，肤色均匀度，第3个月就诊时的皮肤光泽和整体皮肤质量。
结论：研究产品取得了统计学意义，对全球皱纹的显著影响，在健康女性中使用3个月后，皮肤弹性和一系列皮肤属性。这些结果加强了补充胶原蛋白肽和其他微量营养素作为抗衰老护肤的有效成分的证据。
