Abstract：
There has been substantial research interest in finding activities/agents that slow the onset and reduce the severity of numerous age-related diseases/conditions. This assessment indicates that the most studied agent intended to promote health in human population investigations for a broad spectrum of diseases are the statins, with large-scale epidemiological studies addressing numerous health endpoints. The key findings are that statin treatment consistently reduces the occurrence and attenuates the course of numerous non-communicable and contagious pathologies and numerous types of cancer with high mortality rates by about 20-50%. That one agent could affect such a broad based and consistently positive trends in epidemiological studies is unexpected and impressive, along with consistent cell and animal model research. Underlying mechanisms have been proposed that significantly contribute to the spectrum of salutary effects of statins, especially the capacity to activate Nrf2 showing hormetic dose responses in multiple organs and cell types, due to its bioavailability and broad tissue distribution. The widespread use of statins, which has the capacity to enhance human health span, should be considered for experimental exploration as a novel public health strategy that includes practical approaches for reduction of the most common adverse effects of this class of drugs including myalgia/myopathy and transaminitis.
摘要：
在寻找减缓许多与年龄相关的疾病/病症的发作和降低其严重程度的活性/药剂方面已经存在大量的研究兴趣。这项评估表明，在广泛疾病的人群调查中，旨在促进健康的研究最多的药物是他汀类药物，大规模流行病学研究解决了许多健康终点。关键发现是，他汀类药物治疗可持续减少多种非传染性和传染性疾病的发生并减轻多种癌症的进程，高死亡率约为20-50％。一种药物可能会影响流行病学研究中如此广泛且持续的积极趋势，这是出乎意料且令人印象深刻的，以及一致的细胞和动物模型研究。已经提出了潜在的机制，显着有助于他汀类药物的有益作用谱，特别是激活Nrf2的能力，在多种器官和细胞类型中显示出剂量反应，由于其生物利用度和广泛的组织分布。他汀类药物的广泛使用，它有能力提高人类的健康跨度，作为一种新的公共卫生策略，应考虑进行实验探索，其中包括减少此类药物最常见不良反应的实用方法，包括肌痛/肌病和转羊炎。
