Abstract：
Objectives: Post-thrombotic syndrome (PTS) is a frequent and important consequence of deep vein thrombosis (DVT) for Behcet`s disease (BD) patients. Although various clinical scales are used to diagnose PTS, Villalta scale was accepted as the standard tool to diagnose and grade the severity of PTS. Poor quality of life (Qol) in the general population was defined for patients with PTS, however, studies in BD patients with PTS is limited. Our aim was to compare the performance of different scales to assess venous disease in BD patients with a history of DVT and to assess the relationship with quality of life.Methods: Patients with BD (n = 194, M/F:157/37, age:39.1 ± 9.5 years) with a DVT history were investigated. Villalta, VCSS,CEAP scale and SF 36,Veines scales were used to assess venous disease and QoL respectively.Results: Among BD patients, 120 (61.9 %) patients were classified as having PTS by Villalta and of patients 18% had severe PTS. Half of patients with CEAP score <4 were classified as having PTS. Also, 42% of patients with CEAP>4 and almost two third of VCSS classified severe CVD patients was grouped in severe PTS by Villalta scale. VCSS and Villalta classified PTS patients had decreased disease specific and general Qol scores compared to the patients without PTS. Also, severe PTS group (by VCSS) had decreased veines QoL scores and PCS compared to mild/moderate group.Conclusion: BD patients with DVT have a high risk of PTS. Our results show that both Villalta scale and VCSS should be used to assess venous disease BD patients with DVT. However, VCSS classified severity of PTS can show better correlation with venous disease -specific QoL.
摘要：
目的：血栓后综合征（PTS）是Behcet病（BD）患者深静脉血栓形成（DVT）的常见且重要的后果。尽管使用各种临床量表来诊断PTS，Villalta量表被认为是诊断和分级PTS严重程度的标准工具。PTS患者的一般人群生活质量（Qol）较差，然而,BD患者PTS的研究有限。我们的目的是比较不同量表的性能，以评估有DVT病史的BD患者的静脉疾病，并评估与生活质量的关系。方法：对有DVT病史的BD患者（n=194，M/F：157/37，年龄：39.1±9.5岁）进行调查。Villalta,VCSS,CEAP量表和SF36，Veines量表分别用于评估静脉疾病和QoL。结果:BD患者中,120例（61.9％）患者被Villalta分类为患有PTS，其中18％的患者患有严重PTS。CEAP评分<4的患者中有一半被归类为患有PTS。此外，42％的CEAP>4的患者和近三分之二的VCSS分类的重度CVD患者通过Villalta量表分组为重度PTS。与没有PTS的患者相比，VCSS和Villalta分类的PTS患者的疾病特异性和一般Qol评分降低。此外，与轻度/中度组相比,重度PTS组(通过VCSS)的静脉QoL评分和PCS降低.结论:BD合并DVT患者发生PTS的风险较高。我们的结果表明，Villalta量表和VCSS均应用于评估患有DVT的静脉疾病BD患者。然而,VCSS分类的PTS严重程度可以显示出与静脉疾病特异性QoL更好的相关性。
