PDF(Pubmed)
Abstract：
Phosphorescence-based oxygen-sensing hydrogels are a promising platform technology for an upcoming generation of insertable biosensors that are smaller, softer, and potentially more biocompatible than earlier designs. However, much remains unknown about their long-term performance and biocompatibility in vivo. In this paper, we design and evaluate a range of hydrogel sensors that contain oxygen-sensitive phosphors stabilized by micro- and nanocarrier systems. These devices demonstrated consistently good performance and biocompatibility in young adult rats for over three months. This study thoroughly establishes the biocompatibility and long-term suitability of phosphorescence lifetime sensors in vivo, providing the groundwork for expansion of this platform technology into a family of small, unobtrusive biosensors for a range of clinically relevant metabolites.
摘要：
基于磷光的氧传感水凝胶是一种有前途的平台技术，用于下一代更小的可插入生物传感器，更软,并且可能比早期的设计更具生物相容性。然而,它们在体内的长期性能和生物相容性仍然未知。在本文中,我们设计并评估了一系列包含由微米和纳米载体系统稳定的氧敏感磷光体的水凝胶传感器。这些设备在成年大鼠中持续三个月以上表现出良好的性能和生物相容性。这项研究彻底建立了体内磷光寿命传感器的生物相容性和长期适用性，为将该平台技术扩展到一个小型家庭提供了基础，一系列临床相关代谢物的不显眼的生物传感器。
